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Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway

التفاصيل البيبلوغرافية
العنوان: Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway
المؤلفون: In Kyoung Mah, Rachel Soloff, Stephen M. Hedrick, Francesca V. Mariani
المصدر: Stem Cell Reports, Vol 5, Iss 5, Pp 866-880 (2015)
بيانات النشر: Elsevier
سنة النشر: 2015
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Medicine (General), R5-920, Biology (General), QH301-705.5
الوصف: The number of stem/progenitor cells available can profoundly impact tissue homeostasis and the response to injury or disease. Here, we propose that an atypical PKC, Prkci, is a key player in regulating the switch from an expansion to a differentiation/maintenance phase via regulation of Notch, thus linking the polarity pathway with the control of stem cell self-renewal. Prkci is known to influence symmetric cell division in invertebrates; however a definitive role in mammals has not yet emerged. Using a genetic approach, we find that loss of Prkci results in a marked increase in the number of various stem/progenitor cells. The mechanism used likely involves inactivation and symmetric localization of NUMB, leading to the activation of NOTCH1 and its downstream effectors. Inhibition of atypical PKCs may be useful for boosting the production of pluripotent stem cells, multipotent stem cells, or possibly even primordial germ cells by promoting the stem cell/progenitor fate.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2213-6711
العلاقة: http://www.sciencedirect.com/science/article/pii/S2213671115002830Test; https://doaj.org/toc/2213-6711Test; https://doaj.org/article/138011b266514dc3b34539eaeb4a11b6Test
DOI: 10.1016/j.stemcr.2015.09.021
الإتاحة: https://doi.org/10.1016/j.stemcr.2015.09.021Test
https://doaj.org/article/138011b266514dc3b34539eaeb4a11b6Test
رقم الانضمام: edsbas.A64F913A
قاعدة البيانات: BASE
الوصف
تدمد:22136711
DOI:10.1016/j.stemcr.2015.09.021