دورية أكاديمية
Investigating potential anti-proliferative activity of different statins against five cancer cell lines
| العنوان: | Investigating potential anti-proliferative activity of different statins against five cancer cell lines |
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| المؤلفون: | Gauhar Sarbassova, Nurbek Nurlan, Basim Raddam Al shammari, Nidhish Francis, Mohammed Alshammari, Mohamad Aljofan |
| المصدر: | Saudi Pharmaceutical Journal, Vol 31, Iss 5, Pp 727-735 (2023) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Statins, Proliferation, Cancer, Cell signalling, mTOR, P53, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Statins have been reported to have potential anti-proliferative effects through an unknown mechanism. This study aims to investigate the anti-proliferative activities of five statins, including simvastatin, rosuvastatin, fluvastatin, atorvastatin, and pravastatin, against five different cancer cell lines; cervical epithelial carcinoma DoTc2 4510, malignant melanoma A-375, muscle Ewing's sarcoma A-673, hepatocellular carcinoma HUH-7, as well as breast cancer cells MCF-7. At 100 µM, simvastatin and atorvastatin significantly inhibited 70% of cellular proliferation. At the same concentration, rosuvastatin and fluvastatin showed about 50% of inhibition only in A-375 and A-673 cancer cells in a time- and dose-dependent manner. Of all the statin drugs used, pravastatin had the least inhibitory effect on all the cancer cell lines. Western Blot analysis showed a decrease in mTOR level, and the expression of p53 tumour suppression and BCL-2 proteins was relatively elevated compared to the untreated cells. Simvastatin and atorvastatin may inhibit cellular proliferation via BCL-2/p53, Bax/Bak, and PI3K/Akt/mTOR signalling pathways. This is the first research to evaluate the anti-cancer effects of simvastatin, rosuvastatin, fluvastatin, atorvastatin, and pravastatin against five different cell lines from distinct origins and provided a relevant comparison of their efficacies for their anti-proliferative activity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1319-0164 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1319016423000634Test; https://doaj.org/toc/1319-0164Test; https://doaj.org/article/6fbf22e8b0f14167853eecad7588a01eTest |
| DOI: | 10.1016/j.jsps.2023.03.013 |
| الإتاحة: | https://doi.org/10.1016/j.jsps.2023.03.013Test https://doaj.org/article/6fbf22e8b0f14167853eecad7588a01eTest |
| رقم الانضمام: | edsbas.D0F3F40F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13190164 |
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| DOI: | 10.1016/j.jsps.2023.03.013 |