دورية أكاديمية
Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
| العنوان: | Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity |
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| المؤلفون: | Mubeen M. Mosaheb, Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, Matthias Gromeier |
| المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Science |
| الوصف: | Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://doi.org/10.1038/s41467-019-13939-zTest; https://doaj.org/toc/2041-1723Test; https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbfTest |
| DOI: | 10.1038/s41467-019-13939-z |
| الإتاحة: | https://doi.org/10.1038/s41467-019-13939-zTest https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbfTest |
| رقم الانضمام: | edsbas.5F5E3BC6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-019-13939-z |