التفاصيل البيبلوغرافية
| العنوان: |
An integrated map of genetic variation from 1,092 human genomes |
| المؤلفون: |
Altshuler, D.M., Durbin, R.M., Abecasis G.R., Bentley, D.R., Chakravarti, A., Clark, A.G., Donnelly P., Eichler, E.E., Flicek P., Gabriel, S.B., Gibbs, R.A., Green, E.D., Hurles, M.E., Knoppers, B.M., Korbel J.O., Lander, E.S., Lee, C., Lehrach H., Mardis, E.R., Marth G.T., McVean G.A., Nickerson, D.A., Schmidt J.P., Sherry, S.T., Wang J., Wilson, R.K., Dinh H., Kovar, C., Lee, S., Lewis L., Muzny, D., Reid J., Wang, M., Fang X., Guo X., Jian, M., Jiang H., Jin X., Li G., Li J., Li, Y., Li, Z., Liu X., Lu, Y., Ma X., Su, Z., Tai, S., Tang, M., Wang, B., Wang G., Wu H., Wu, R., Yin, Y., Zhang W., Zhao J., Zhao, M., Zheng X., Zhou, Y., Gupta, N., Clarke L., Leinonen, R., Smith, R.E., Zheng-Bradley X., Grocock, R., Humphray, S., James, T., Kingsbury, Z., Sudbrak, R., Albrecht, M.W., Amstislavskiy V.S., Borodina, T.A., Lienhard, M., Mertes F., Sultan, M., Timmermann, B., Yaspo, M.-L., Fulton L., Fulton, R., Weinstock G.M., Balasubramaniam, S., Burton J., Danecek P., Keane, T.M., Kolb-Kokocinski, A., McCarthy, S., Stalker J., Quail, M., Davies, C.J., Gollub J., Webster, T., Wong, B., Zhan, Y., Auton, A., Yu F., Bainbridge, M., Challis, D., Evani, U.S., Lu J., Nagaswamy, U., Sabo, A., Wang, Y., Yu J., Coin L.J.M., Fang L., Li Q., Lin H., Liu, B., Luo, R., Qin, N., Shao H., Xie, Y., Ye, C., Yu, C., Zhang F., Zheng H., Zhu H., Garrison, E.P., Kural, D., Lee W.-P., Fung Leong W., Ward, A.N., Wu J., Zhang, M., Griffin L., Hsieh, C.-H., Mills, R.E., Shi X., Von Grotthuss, M., Zhang, C., Daly, M.J., Depristo, M.A., Banks, E., Bhatia G., Carneiro, M.O., Del Angel G., Genovese G., Handsaker, R.E., Hartl, C., McCarroll, S.A., Nemesh J.C., Poplin, R.E., Schaffner, S.F., Shakir, K., Yoon, S.C., Lihm J., Makarov V., Jin H., Kim W., Cheol Kim, K., Rausch, T., Beal, K., Cunningham F., Herrero J., McLaren W.M., Ritchie G.R.S., Gottipati, S., Keinan, A., Rodriguez-Flores J.L., Sabeti P.C., Grossman, S.R., Tabrizi, S., Tariyal, R., Cooper, D.N., Ball, E.V., Stenson P.D., Barnes, B., Bauer, M., Keira Cheetham, R., Cox, T., Eberle, M., Kahn, S., Murray L., Peden J., Shaw, R., Ye, K., Batzer, M.A., Konkel, M.K., Walker J.A., MacArthur, D.G., Lek, M., Herwig, R., Shriver, M.D., Bustamante, C.D., Byrnes J.K., De La Vega F.M., Gravel, S., Kenny, E.E., Kidd J.M., Maples, B.K., Moreno-Estrada, A., Zakharia F., Halperin, E., Baran, Y., Craig, D.W., Christoforides, A., Homer, N., Izatt, T., Kurdoglu, A.A., Sinari, S.A., Squire, K., Xiao, C., Sebat J., Bafna V., Burchard, E.G., Hernandez, R.D., Gignoux, C.R., Haussler, D., Katzman, S.J., James Kent W., Howie, B., Ruiz-Linares, A., Dermitzakis, E.T., Lappalainen, T., Devine, S.E., Maroo, A., Tallon L.J., Rosenfeld J.A., Michelson L.P., Min Kang H., Anderson P., Angius, A., Bigham, A., Blackwell, T., Busonero F., Cucca F., Fuchsberger, C., Jones, C., Jun G., Lyons, R., Maschio, A., Porcu, E., Reinier F., Sanna, S., Schlessinger, D., Sidore, C., Tan, A., Kate Trost, M., Awadalla P., Hodgkinson, A., Lunter G., Marchini J.L., Myers, S., Churchhouse, C., Delaneau O., Gupta-Hinch, A., Iqbal, Z., Mathieson I., Rimmer, A., Xifara, D.K., Oleksyk, T.K., Fu, Y., Xiong, M., Jorde L., Witherspoon, D., Xing J., Browning, B.L., Alkan, C., Hajirasouliha I., Hormozdiari F., Ko, A., Sudmant P.H., Chen, K., Chinwalla, A., Ding L., Dooling, D., Koboldt, D.C., McLellan, M.D., Wallis J.W., Wendl, M.C., Zhang Q., Tyler-Smith, C., Albers, C.A., Ayub Q., Chen, Y., Coffey, A.J., Colonna V., Huang, N., Jostins L., Li H., Scally, A., Walter, K., Xue, Y., Zhang, Y., Gerstein, M.B., Abyzov, A., Balasubramanian, S., Chen J., Clarke, D., Habegger L., Harmanci, A.O., Jin, M., Khurana, E., Jasmine Mu X., Sisu, C., Degenhardt J., Stütz, A.M., Church, D., Michaelson J.J., Blackburne, B., Lindsay, S.J., Ning, Z., Frankish, A., Harrow J., Mu X.J., Fowler G., Hale W., Kalra, D., Barker J., Kelman G., Kulesha, E., Radhakrishnan, R., Roa, A., Smirnov, D., Streeter I., Toneva I., Vaughan, B., Ananiev V., Belaia, Z., Beloslyudtsev, D., Bouk, N., Chen, C., Cohen, R., Cook, C., Garner J., Hefferon, T., Kimelman, M., Liu, C., Lopez J., Meric P., O'Sullivan, C., Ostapchuk, Y., Phan L., Ponomarov, S., Schneider V., Shekhtman, E., Sirotkin, K., Slotta, D., Zhang H., Barnes, K.C., Beiswanger, C., Cai H., Cao H., Gharani, N., Henn, B., Jones, D., Kaye J.S., Kent, A., Kerasidou, A., Mathias, R., Ossorio P.N., Parker, M., Reich, D., Rotimi, C.N., Royal, C.D., Sandoval, K., Su, Y., Tian, Z., Tishkoff, S., Toji L.H., Via, M., Yang H., Yang L., Zhu J., Bodmer W., Bedoya G., Ming, C.Z., Yang G., Jia You, C., Peltonen L., Garcia-Montero, A., Orfao, A., Dutil J., Martinez-Cruzado J.C., Brooks L.D., Felsenfeld, A.L., McEwen J.E., Clemm, N.C., Duncanson, A., Dunn, M., Guyer, M.S., Peterson J.L., Lacroute P. |
| المصدر: |
Nature |
| سنة النشر: |
2012 |
| المجموعة: |
Bilkent University: Institutional Repository |
| مصطلحات موضوعية: |
transcription factor, untranslated RNA, algorithm, evolutionary biology, genetic analysis, genetic variation, genomics, human evolution, integrated approach, map, natural selection, polymorphism, article, binding site, chromatin immunoprecipitation, exome, frameshift mutation, gain of function mutation, gene frequency, gene linkage disequilibrium, genetic association, genetic variability, genotype, haplotype map, human, human genome, human genome project, indel mutation, loss of function mutation, priority journal |
| الوصف: |
By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and common variants, and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations. © 2012 Macmillan Publishers Limited. All rights reserved. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://dx.doi.org/10.1038/nature11632Test; 280836; http://hdl.handle.net/11693/21285Test |
| DOI: |
10.1038/nature11632 |
| الإتاحة: |
https://doi.org/10.1038/nature11632Test
http://hdl.handle.net/11693/21285Test |
| رقم الانضمام: |
edsbas.8A2D6BCD |
| قاعدة البيانات: |
BASE |
