دورية أكاديمية
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4
| العنوان: | Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 |
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| المؤلفون: | Shuang Qin, Linping Xu, Ming Yi, Shengnan Yu, Kongming Wu, Suxia Luo |
| المصدر: | Molecular Cancer, Vol 18, Iss 1, Pp 1-14 (2019) |
| بيانات النشر: | BMC |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Immunotherapy, Immune checkpoint, LAG-3, TIM-3, TIGIT, VISTA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | The emergence of immune checkpoint inhibitors (ICIs), mainly including anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibodies (mAbs), has shaped therapeutic landscape of some type of cancers. Despite some ICIs have manifested compelling clinical effectiveness in certain tumor types, the majority of patients still showed de novo or adaptive resistance. At present, the overall efficiency of immune checkpoint therapy remains unsatisfactory. Exploring additional immune checkpoint molecules is a hot research topic. Recent studies have identified several new immune checkpoint targets, like lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), T cell immunoglobulin and ITIM domain (TIGIT), V-domain Ig suppressor of T cell activation (VISTA), and so on. The investigations about these molecules have generated promising results in preclinical studies and/or clinical trials. In this review, we discussed the structure and expression of these newly-characterized immune checkpoints molecules, presented the current progress and understanding of them. Moreover, we summarized the clinical data pertinent to these recent immune checkpoint molecules as well as their application prospects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476-4598 |
| العلاقة: | http://link.springer.com/article/10.1186/s12943-019-1091-2Test; https://doaj.org/toc/1476-4598Test; https://doaj.org/article/7f6ea285e3834011a1ff496a2f1048a8Test |
| DOI: | 10.1186/s12943-019-1091-2 |
| الإتاحة: | https://doi.org/10.1186/s12943-019-1091-2Test https://doaj.org/article/7f6ea285e3834011a1ff496a2f1048a8Test |
| رقم الانضمام: | edsbas.CA011AD4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14764598 |
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| DOI: | 10.1186/s12943-019-1091-2 |