التفاصيل البيبلوغرافية
| العنوان: |
The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes |
| المؤلفون: |
Fank, Hélène, Weekers, Laurent, Lovinfosse, Pierre, Pottel, Hans, Seidel, Laurence, Jadoul, Alexandre, Bouquegneau, Antoine, Bonvoisin, Catherine, Bovy, Christophe, Grosch, Stephanie, Erpicum, Pauline, Hustinx, Roland, Jouret, François |
| المصدر: |
Frontiers in Transplantation ; volume 2 ; ISSN 2813-2440 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| الوصف: |
Introduction [ 18 F]FDG PET/CT noninvasively disproves acute kidney allograft rejection (AR) in kidney transplant recipients (KTRs) with suspected AR. However, the correlation of biopsy-based Banff vs. PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [ 18 F]FDG PET/CT at one year post suspected AR. Methods From 2012 to 2019, 114 [ 18 F]FDG-PET/CTs were prospectively performed in 105 adult KTRs who underwent per cause transplant biopsies. Ordinal logistic regression assessed the correlation between the extent of histological inflammation and the mean standardized [ 18 F]FDG uptake values (mSUV mean ). Functional outcomes of kidney allografts were evaluated at one year post per cause biopsy and correlated to mSUVmean. Results A significant correlation between mSUV mean and acute Banff score was found, with an adjusted R 2 of 0.25. The mSUV mean was significantly different between subgroups of “total i”, with 2.30 ± 0.71 in score 3 vs. 1.68 ± 0.24 in score 0. Neither the function nor the survival of the graft at one year was statistically related to mSUV mean . Discussion [ 18 F]FDG-PET/CT may help noninvasively assess the severity of kidney allograft inflammation in KTRs with suspected AR, but it does not predict graft outcomes at one year. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/frtra.2023.1236751 |
| DOI: |
10.3389/frtra.2023.1236751/full |
| الإتاحة: |
https://doi.org/10.3389/frtra.2023.1236751Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.E5D0CD57 |
| قاعدة البيانات: |
BASE |
