دورية أكاديمية
Primary Bone Marrow Hodgkin's Lymphoma Debuting As Hemophagocytic Lymphohistiocytosis in a Patient With HIV.
| العنوان: | Primary Bone Marrow Hodgkin's Lymphoma Debuting As Hemophagocytic Lymphohistiocytosis in a Patient With HIV. |
|---|---|
| المؤلفون: | Navarrete, Anthony M, Machin, Nicoletta, Jawad, Majd |
| المصدر: | Cureus ; ISSN:2168-8184 ; Volume:16 ; Issue:5 |
| بيانات النشر: | PubMed Central |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | classical hodgkin's, hematology-oncology, hemophagocytic lymphohistiocytosis (hlh), hiv aids, lymphoma, primary bone marrow lymphoma |
| الوصف: | The development of Hodgkin's lymphoma (HL) is a known complication in patients with human immunodeficiency virus (HIV) infection. Extranodal involvement, specifically primary bone marrow Hodgkin's lymphoma (PBMHL) is a rare manifestation that has been reported in HIV-positive patients and may represent a distinct entity from HIV-associated HL. We present a case of PBMHL presenting with hemophagocytic lymphohistiocytosis (HLH) in an HIV-positive patient. The 55-year-old male with HIV/AIDS presented with abdominal pain, diarrhea, and fever, leading to hospital admission. Despite initial treatment, he deteriorated, prompting re-admission and investigation revealing pancytopenia and elevated inflammatory markers, suggestive of HLH. Subsequent bone marrow biopsy unexpectedly revealed PBMHL. Treatment with HLH-directed therapy and the HLH-94 protocol resulted in significant clinical improvement. This case underscores the importance of recognizing atypical lymphoproliferative presentations in HIV/AIDS patients and the need for interdisciplinary collaboration in complex cases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.7759/cureus.60864Test; https://pubmed.ncbi.nlm.nih.gov/38910743Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192211Test/ |
| DOI: | 10.7759/cureus.60864 |
| الإتاحة: | https://doi.org/10.7759/cureus.60864Test https://pubmed.ncbi.nlm.nih.gov/38910743Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192211Test/ |
| حقوق: | Copyright © 2024, Navarrete et al. |
| رقم الانضمام: | edsbas.1E34DEC3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7759/cureus.60864 |
|---|