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c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA

التفاصيل البيبلوغرافية
العنوان: c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA
المؤلفون: Bingyan Li, Guang Zhang, Zhongyu Wang, Yang Yang, Chenfeng Wang, Debao Fang, Kaiyue Liu, Fang Wang, Yide Mei
المصدر: Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
بيانات النشر: Nature Publishing Group
سنة النشر: 2021
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Cytology, QH573-671
الوصف: The c-Myc oncoprotein plays a prominent role in cancer initiation, progression, and maintenance. Long noncoding RNAs (lncRNAs) are recently emerging as critical regulators of the c-Myc signaling pathway. Here, we report the lncRNA USP2-AS1 as a direct transcriptional target of c-Myc. Functionally, USP2-AS1 inhibits cellular senescence and acts as an oncogenic molecule by inducing E2F1 expression. Mechanistically, USP2-AS1 associates with the RNA-binding protein G3BP1 and facilitates the interaction of G3BP1 to E2F1 3′-untranslated region, thereby leading to the stabilization of E2F1 messenger RNA. Furthermore, USP2-AS1 is shown as a mediator of the oncogenic function of c-Myc via the regulation of E2F1. Together, these findings suggest that USP2-AS1 is a negative regulator of cellular senescence and also implicates USP2-AS1 as an important player in mediating c-Myc function.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2041-4889
العلاقة: https://doi.org/10.1038/s41419-021-04330-2Test; https://doaj.org/toc/2041-4889Test; https://doaj.org/article/310ce978f7344e2491ec5770047dd107Test
DOI: 10.1038/s41419-021-04330-2
الإتاحة: https://doi.org/10.1038/s41419-021-04330-2Test
https://doaj.org/article/310ce978f7344e2491ec5770047dd107Test
رقم الانضمام: edsbas.AE43635F
قاعدة البيانات: BASE
الوصف
تدمد:20414889
DOI:10.1038/s41419-021-04330-2