دورية أكاديمية
Chemotherapy and tumor microenvironment of pancreatic cancer
| العنوان: | Chemotherapy and tumor microenvironment of pancreatic cancer |
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| المؤلفون: | Qiaofei Liu, Quan Liao, Yupei Zhao |
| المصدر: | Cancer Cell International, Vol 17, Iss 1, Pp 1-17 (2017) |
| بيانات النشر: | BMC |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Pancreatic cancer, Tumor microenvironment, Chemotherapy, Myeloid derived suppressor cells, Tumor associated macrophages, Pancreatic stellate cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and profound infiltrations of immunosuppressive cells. Interactions between stromal cells and cancer cells play vital roles to affect the biological behaviors of pancreatic cancer. Targeting the stromal components of pancreatic cancer has shown promising results. In addition to the direct toxic effects of chemotherapeutic drugs on cancer cells, they can also remodel the TME, eventually affecting their efficacy. Herein, we reviewed the following four aspects; (1) clinical landmark advances of chemotherapy in pancreatic cancer, since 2000; (2) interactions and mechanisms between stromal cells and pancreatic cancer cells; (3) remodeling effects and mechanisms of chemotherapy on TME; (4) targeting stromal components in pancreatic cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1475-2867 |
| العلاقة: | http://link.springer.com/article/10.1186/s12935-017-0437-3Test; https://doaj.org/toc/1475-2867Test; https://doaj.org/article/6e80807e43764f55be30a976096e829fTest |
| DOI: | 10.1186/s12935-017-0437-3 |
| الإتاحة: | https://doi.org/10.1186/s12935-017-0437-3Test https://doaj.org/article/6e80807e43764f55be30a976096e829fTest |
| رقم الانضمام: | edsbas.1F451B40 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14752867 |
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| DOI: | 10.1186/s12935-017-0437-3 |