التفاصيل البيبلوغرافية
| العنوان: |
Clinical assessment of ramosetron HCl oral preparation in the treatment of nausea and vomiting induced by cisplatin: a multicenter, randomized, parallel-design, double-blind comparative study with ondansetron HCl. |
| المؤلفون: |
Noda K (AUTHOR), Ikeda M (AUTHOR), Taguchi T (AUTHOR), Kanamaru R (AUTHOR), Ichijyo M (AUTHOR), Okada K (AUTHOR), Yano S (AUTHOR), Sugimoto O (AUTHOR), Fukuoka M (AUTHOR), Nakashima M (AUTHOR) |
| المصدر: |
Current Therapeutic Research. Oct2002, Vol. 63 Issue 10, p636-648. 13p. |
| مستخلص: |
Background: Nausea and vomiting induced by anticancer drugs cause considerable stress to patients and complicate drug administration and/or cause patients to refuse further courses of therapy. Oral antiemetics, such as ondansetron HCl, were developed to provide a wider selection of drugs to treat chemotherapy-induced nausea and vomiting. Ramosetron HCl oral preparation (intraoral disintegrator) was specially formulated to be taken without water. Studies have shown that ramosetron oral preparation has potent inhibitory effects on cisplatin-induced vomiting.Objective: This multicenter, randomized, parallel-design, double-blind comparative study examined the efficacy, tolerability, and usefulness of ramosetron oral preparation compared with ondansetron HCl oral preparation in inhibiting nausea/vomiting (including retching) induced by the anticancer drug cisplatin.Methods: Japanese inpatients aged >/= 20 years with cancer were eligible. Patients received either a single IV administration or
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| قاعدة البيانات: |
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