التفاصيل البيبلوغرافية
| العنوان: |
PICALM mRNA Expression in the Blood of Patients with Neurodegenerative Diseases and Geriatric Depression. |
| المؤلفون: |
Hiroshi Kumon1, Yuta Yoshino1, Yu Funahashi1, Hiroaki Mori1, Mariko Ueno1, Yuki Ozaki1, Kiyohiro Yamazaki1, Shinichiro Ochi1, Takaaki Mori1, Jun-ichi Iga1 igajunichi@hotmail.com, Masahiro Nagai2, Masahiro Nomoto2, Shu-ichi Ueno1, Kumon, Hiroshi1 (AUTHOR), Yoshino, Yuta1 (AUTHOR), Funahashi, Yu1 (AUTHOR), Mori, Hiroaki1 (AUTHOR), Ueno, Mariko1 (AUTHOR), Ozaki, Yuki1 (AUTHOR), Yamazaki, Kiyohiro1 (AUTHOR) |
| المصدر: |
Journal of Alzheimer's Disease. 2021, Vol. 79 Issue 3, p1055-1062. 8p. |
| مصطلحات موضوعية: |
*NEURODEGENERATION, *LEWY body dementia, *GERIATRIC psychiatry, *MENTAL depression, *MESSENGER RNA, *PARKINSON'S disease, *RNA metabolism, *RESEARCH, *ALZHEIMER'S disease, *RESEARCH methodology, *CASE-control method, *RNA, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *MEMBRANE proteins |
| مستخلص: |
Background: Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a validated genetic risk factor for late-onset Alzheimer's disease (AD) and is associated with other neurodegenerative diseases. However, PICALM expression in the blood of neurodegenerative diseases remains elusive.Objective: This study aimed to assess the usefulness of PICALM expression levels in the blood of patients with AD, Parkinson's disease (PD), dementia with Lewy bodies (DLB), and geriatric major depressive disorder (MDD) as a diagnostic biomarker.Methods: In total, 45, 20, 21, and 19 patients with AD, PD, DLB, and geriatric MDD, respectively, and 54 healthy controls (HCs) were enrolled in the study. Expression data from Gene Expression Omnibus database (GSE97760), (GSE133347) and (GSE98793), (GSE48350), and (GSE144459) were used to validate the ability of biomarkers in the blood of patients with AD, PD, geriatric MDD, and a postmortem human AD brain and animal model of AD (3xTg-AD mouse), respectively.Results: PICALM mRNA expression in human blood was significantly increased in patients with AD compared with that in HCs. PICALM mRNA expression and age were negatively correlated only in patients with AD. PICALM mRNA expression in human blood was significantly lower in patients with PD than in HCs. No changes in PICALM mRNA expression were found in patients with DLB and geriatric MDD.Conclusion: PICALM mRNA expression in blood was higher in patients with AD, but lower in patients with PD, which suggests that PICALM mRNA expression in human blood may be a useful biomarker for differentiating neurodegenerative diseases and geriatric MDD. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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