التفاصيل البيبلوغرافية
| العنوان: |
Insulin Glargine Maintains Equivalent Glycemic Control and Better Lipometabolic Control than NPH Insulin in Type 1 Diabetes Patients Who Missed a Meal. |
| المؤلفون: |
C. Rosak1 |
| المصدر: |
Hormone & Metabolic Research. Aug2008, Vol. 40 Issue 8, p544-548. 5p. |
| مصطلحات موضوعية: |
*HYPOGLYCEMIC agents, *HORMONES, *HUMAN anatomy, *SECRETION |
| مستخلص: |
Our goal was to investigate blood glucose and lipometabolism control in type 1 diabetes patients who missed breakfast and the accompanying insulin injection of NPH insulin (NPH) or insulin glargine (glargine) as part of a basal-bolus regimen. This was a multi-center, open-label, controlled study in adults (?18 years) with HbA 1c?11.5% on insulin therapy with NPH as basal insulin. Patients were randomized to receive prandial insulin plus either bedtime glargine (n=28) or NPH (n=32). Insulin was titrated to target fasting blood glucose levels 80-130?mg/dl at 06:00-07:00. Patients had no intake of insulin or food between 22:00 and 12:00 the next day. The change in blood glucose levels (07:00-11:00) was similar (27.5?mg/dl vs. 35.4?mg/dl), but the mean blood glucose level was higher with glargine vs. NPH at 22:00 (158.2?mg/dl vs. 130.2?mg/dl). During the period without insulin or food intake, blood glucose decreased with glargine (-25.8?mg/dl) and increased with NPH (+9.1?mg/dl; p=0.0284). Nonesterified fatty acid (07:00 and 09:00-12:00) and ?-hydroxybutyrate (07:00 and 10:00-12:00) levels were lower with glargine vs. NPH (both p<0.05). For patients who miss a morning meal, glargine is associated with maintained glycemic and lipometabolic control compared with NPH insulin. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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