التفاصيل البيبلوغرافية
| العنوان: |
The Conformation of cyclo(-D-Pro-Ala4-) as a Model for Cyclic Pentapeptides of the DL4 Type. |
| المؤلفون: |
Heller, Markus1,2, Martin Sukopp1,3, Natia Tsomaia4, Michael John1,5, Dale F. Mierke4, Bernd Reif6, Horst Kessler1 Horst.Kessler@ch.tum.de |
| المصدر: |
Journal of the American Chemical Society. 10/25/2006, Vol. 128 Issue 42, p13806-13814. 9p. 11 Diagrams, 4 Charts. |
| مصطلحات موضوعية: |
*CYCLIC peptides, *ORGANIC cyclic compounds, *NUCLEAR magnetic resonance, *CHEMICAL bonds, *BIOACTIVE compounds, *CHEMICAL structure, *PHYSICAL & theoretical chemistry |
| مستخلص: |
The conformation of the cyclic pentapeptide cyclo(-D-Pro-Ala4-) in solution and in the solid state was reinvestigated using modern NMR techniques. To allow unequivocal characterization of hydrogen bonds, relaxation behavior, and intramolecular distances, differently labeled isotopomers were synthesized. The NMR results, supported by extensive MD simulations, demonstrate unambiguously that the preferred conformation previously described by us, but recently questioned, is indeed correct. The validation of the conformational preferences of this cyclic peptide is important given that this system is a template for several bioactive compounds and for controlled ‘spatial screening’ for the search of bioactive conformations. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
