التفاصيل البيبلوغرافية
| العنوان: |
Escherichia coli-Cloned CFTR Loci Relevant for Human Artificial Chromosome Therapy. |
| المؤلفون: |
Lucia Rocchi, Carla Braz, Sonja Cattani, Anabela Ramalho, Sulith Christan, Marlene Edlinger, Fiorentina Ascenzioni, Andreas Laner, Simone Kraner, Margarida Amaral, Dirk Schindelhauer |
| المصدر: |
Human Gene Therapy. Sep2010, Vol. 21 Issue 9, p1077-1092. 16p. |
| مصطلحات موضوعية: |
*BACTERIAL genetics, *HUMAN chromosomes, *GENE expression, *ESCHERICHIA coli, *CYSTIC fibrosis, *BIOLOGICAL membranes, *CELL culture |
| مستخلص: |
In this report by Rocchi et al.,the authors construct and characterize a human artificial chromosome (HAC) gene expression system capable of reconstructing and delivering the complete cystic fibrosis transmembrane conductance regulator (CFTR) gene. The efficacy of this system was evaluated in vitrousing cell cultures. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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