التفاصيل البيبلوغرافية
| العنوان: |
Prevalence and Impact on Mortality of Colonization and Super-Infection by Carbapenem-Resistant Gram-Negative Organisms in COVID-19 Hospitalized Patients. |
| المؤلفون: |
Casale, Roberto1,2 (AUTHOR) roberto.casale.cr@gmail.com, Bianco, Gabriele1 (AUTHOR) cominisara@gmail.com, Bastos, Paulo3 (AUTHOR) pauloandrediasbastos01@gmail.com, Comini, Sara1,2 (AUTHOR) matteo.boattini@unito.it, Corcione, Silvia4 (AUTHOR) silvia.corcione@unito.it, Boattini, Matteo1,2,5 (AUTHOR) rossana.cavallo@unito.it, Cavallo, Rossana1,2 (AUTHOR) cristina.costa@unito.it, Rosa, Francesco Giuseppe De4,6 (AUTHOR) francescogiuseppe.derosa@unito.it, Costa, Cristina1,2 (AUTHOR) |
| المصدر: |
Viruses (1999-4915). Sep2023, Vol. 15 Issue 9, p1934. 13p. |
| مصطلحات موضوعية: |
*GRAM-negative bacteria, *CARBAPENEM-resistant bacteria, *COVID-19, *KLEBSIELLA infections, *ACINETOBACTER baumannii, *SUPERINFECTION |
| مستخلص: |
Background: The relationship between superinfection by multidrug-resistant Gram-negative bacteria and mortality among SARS-CoV-2 hospitalized patients is still unclear. Carbapenem-resistant Acinetobacter baumannii and carbapenemase-producing Enterobacterales are among the most frequently isolated species when it comes to hospital-acquired superinfections among SARS-CoV-2 patients. Methods: Herein, a retrospective study was carried out using data from adult patients hospitalized for COVID-19. The interaction between in-hospital mortality and rectal carriage and superinfection by carbapenemase-producing Enterobacterales and/or carbapenem-resistant Acinetobacter baumannii was assessed. Results: The incidence of KPC-producing Klebsiella pneumoniae and/or carbapenem-resistant Acinetobacter baumannii rectal carriage was 30%. Bloodstream infection and/or pneumonia due to KPC-producing Klebsiella pneumoniae and/or carbapenem-resistant Acinetobacter baumannii occurred in 20% of patients. A higher Charlson comorbidity index (OR 1.41, 95% CI 1.24–1.59), being submitted to invasive mechanical ventilation/ECMO ≥ 96 h (OR 6.34, 95% CI 3.18–12.62), being treated with systemic corticosteroids (OR 4.67, 95% CI 2.43–9.05) and having lymphopenia at the time of admission (OR 0.54, 95% CI 0.40–0.72) were the features most strongly associated with in-hospital mortality. Conclusions: Although KPC-producing Klebsiella pneumoniae and/or carbapenem-resistant Acinetobacter baumannii rectal carriage, and/or bloodstream infection/pneumonia were diagnosed in a remarkable percentage of COVID-19 patients, their impact on in-hospital mortality was not significant. Further studies are needed to assess the burden of antimicrobial resistance as a legacy of COVID-19 in order to identify future prevention opportunities. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder