التفاصيل البيبلوغرافية
| العنوان: |
Considerable decrease in antibodies against hepatitis B surface antigen following kidney transplantation. |
| المؤلفون: |
Moal, Valérie1,2 vmoal@ap-hm.fr, Motte, Anne3 anne.motte@ap-hm.fr, Vacher-Coponat, Henri1,4 Henri.VACHERCOPONAT@ap-hm.fr, Tamalet, Catherine3 catherine.tamalet@ap-hm.fr, Berland, Yvon1,4 yvon.berland@ap-hm.fr, Colson, Philippe2,3 philippe.colson@univ-amu.fr |
| المصدر: |
Journal of Clinical Virology. Jul2015, Vol. 68, p32-36. 5p. |
| مصطلحات موضوعية: |
*IMMUNOGLOBULINS, *HEPATITIS associated antigen, *KIDNEY transplantation, *HOSPITAL admission & discharge, *SEROLOGY |
| مستخلص: |
Background Immunization against hepatitis B virus (HBV) in kidney transplantation (KT) candidates and recipients is recommended. If anti-HBV surface antigen antibody (anti-HBsAb) titer of 10 IU/L is admitted to be protective, the optimal threshold, at and after KT, is unknown. In addition, the natural evolution of anti-HBsAb titers after KT is not reported. Objectives To describe rates of protective immunity to HBV at time of KT (baseline) and evolution of anti-HBsAb titers during the following year. Study design We retrospectively analyzed HBV serology at baseline, 15 days, and 4 and 12 months post-KT. No patient received vaccination during the study period, but information about previous vaccination was unavailable. Results At baseline 80% of 141 recipients had anti-HBsAb titer ≥10 IU/L. Among these 113 patients, 84 had subsequent HBV serologies at day 15 and month 4, and 67 had also serology at month 12. At month 12, 25% of patients had lost protective anti-HBsAb titers ( p < 0.001). The duration of protective anti-HBsAb titers was significantly longer when the initial titer was ≥ 100 IU/L versus <100 IU/L (log-rank test p < 0.0001). Protective titers at month 12 persisted in 93% of patients with initial titer ≥100 IU/L compared to 33% with 10–100 IU/L titer ( p < 0.0001). In contrast, duration of protective titers did not differ according to the anti-HBV core antigen antibody status at baseline. Conclusions Despite a high prevalence of protective anti-HBsAb titer at KT, the loss of protective immunity during the following year was considerable, particularly when initial anti-HBsAb titer was <100 IU/L. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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