التفاصيل البيبلوغرافية
| العنوان: |
Antibiotic susceptibility of Helicobacter pylori in Iceland. |
| المؤلفون: |
Gunnarsdottir, Anna Ingibjorg1,2 (AUTHOR) annaig@landspitali.is, Gudjonsson, Hallgrimur3,4 (AUTHOR), Hardardottir, Hjordis5 (AUTHOR), Jonsdottir, Karen Drofn2 (AUTHOR), Bjornsson, Einar Stefan3,4 (AUTHOR) |
| المصدر: |
Infectious Diseases. 2017, Vol. 49 Issue 9, p647-654. 8p. |
| مصطلحات موضوعية: |
*HELICOBACTER disease diagnosis, *ANTIBIOTICS, *BIOPSY, *CHI-squared test, *DRUG resistance in microorganisms, *GASTROSCOPY, *HELICOBACTER diseases, *HELICOBACTER pylori, *LONGITUDINAL method, *METRONIDAZOLE, *MICROBIAL sensitivity tests, *PROBABILITY theory, *QUINOLONE antibacterial agents, *RESEARCH funding, *SEX distribution, *T-test (Statistics), *TETRACYCLINE, *UREASE, *AMPICILLIN, *DESCRIPTIVE statistics, *CLARITHROMYCIN |
| مصطلحات جغرافية: |
ICELAND |
| مستخلص: |
Background:Increasing resistance ofHelicobacter pylori (H. pylori)to antibiotics calls for constant re-evaluation of multidrug regimens that have been used to eradicate the infection. The aim of this study was to evaluate the current antibiotic susceptibility ofH. pyloriin an Icelandic cohort. Methods:Patients referred for gastroscopy were recruited prospectively. Those found to have a positive rapid urease test were included in the study. Susceptibility testing was conducted by the Epsilometer test (E-test) method for ampicillin, clarithromycin, levofloxacin, metronidazole and tetracycline. Results were obtained after three days of incubation in microaerophilic conditions at 37 °C, except for the metronidazole were the first 24 hours were anaerobic. Results:Of the 613 patients who underwent gastroscopy, 138 (23%) had a positive rapid urease test.H. pyloriwas successfully cultured from 105 (76%) of the urease test positive patients and the isolates were tested for antibiotic susceptibility. Five patients had priorH. pylorieradication. Antibiotic resistance for ampicillin, clarithromycin, levofloxacin, metronidazole and tetracycline was 0%, 9%, 4%, 1% and 0%, respectively. If those who had previously undergone eradication treatment were excluded, the resistance was 0%, 6%, 3%, 1% and 0%, respectively. Clarithromycin resistance was higher amongst women than men, 13% vs. 5%, however, not significantly. Clarithromycin resistance was 60% amongst those who had previously received eradication treatment compared to 6% of those who had not (p < .0001). Conclusions:Clarithromycin resistance amongst theH. pyloriisolates can be considered relatively low. Therefore, in the current cohort, standard triple-drug clarithromycin-containing regimen should remain the first-line treatment againstH. pylori. [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
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