التفاصيل البيبلوغرافية
| العنوان: |
Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes. |
| المؤلفون: |
Triolo, Taylor M.1 triolo@childrenscolorado.org, Fouts, Alexandra1, Pyle, Laura2, Liping Yu1, Gottlieb, Peter A.1, Steck, Andrea K.1, Yu, Liping, Type 1 Diabetes TrialNet Study Group |
| المصدر: |
Diabetes Care. Feb2019, Vol. 42 Issue 2, p192-199. 8p. 2 Charts, 2 Graphs. |
| مصطلحات موضوعية: |
*AUTOANTIBODY analysis, *AUTOANTIBODIES, *COMPARATIVE studies, *DISEASE susceptibility, *ECOLOGY, *ENZYMES, *EPIDEMIOLOGICAL research, *IMMUNITY, *INSULIN, *TYPE 1 diabetes, *ISLANDS of Langerhans, *RESEARCH methodology, *MEDICAL cooperation, *MEDICAL screening, *RESEARCH, *TWINS, *SYMPTOMS, *EVALUATION research, *DISEASE progression |
| مستخلص: |
Objective: There are variable reports of risk of concordance for progression to islet autoantibodies and type 1 diabetes in identical twins after one twin is diagnosed. We examined development of positive autoantibodies and type 1 diabetes and the effects of genetic factors and common environment on autoantibody positivity in identical twins, nonidentical twins, and full siblings.Research Design and Methods: Subjects from the TrialNet Pathway to Prevention Study (N = 48,026) were screened from 2004 to 2015 for islet autoantibodies (GAD antibody [GADA], insulinoma-associated antigen 2 [IA-2A], and autoantibodies against insulin [IAA]). Of these subjects, 17,226 (157 identical twins, 283 nonidentical twins, and 16,786 full siblings) were followed for autoantibody positivity or type 1 diabetes for a median of 2.1 years.Results: At screening, identical twins were more likely to have positive GADA, IA-2A, and IAA than nonidentical twins or full siblings (all P < 0.0001). Younger age, male sex, and genetic factors were significant factors for expression of IA-2A, IAA, one or more positive autoantibodies, and two or more positive autoantibodies (all P ≤ 0.03). Initially autoantibody-positive identical twins had a 69% risk of diabetes by 3 years compared with 1.5% for initially autoantibody-negative identical twins. In nonidentical twins, type 1 diabetes risk by 3 years was 72% for initially multiple autoantibody-positive, 13% for single autoantibody-positive, and 0% for initially autoantibody-negative nonidentical twins. Full siblings had a 3-year type 1 diabetes risk of 47% for multiple autoantibody-positive, 12% for single autoantibody-positive, and 0.5% for initially autoantibody-negative subjects.Conclusions: Risk of type 1 diabetes at 3 years is high for initially multiple and single autoantibody-positive identical twins and multiple autoantibody-positive nonidentical twins. Genetic predisposition, age, and male sex are significant risk factors for development of positive autoantibodies in twins. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder