التفاصيل البيبلوغرافية
| العنوان: |
Paeoniflorin attenuates gestational diabetes via Akt/mTOR pathway in a rat model. |
| المؤلفون: |
Yonghua Zhang1, Yulin Liang1, Huiqiao Liu1, Ying Huang1, Hongmei Li1, Bo Chen1 chenbochenbo_1234@163.com |
| المصدر: |
Food & Nutrition Research. 2020, Vol. 64, p1-9. 9p. |
| مصطلحات موضوعية: |
*AMINOGLYCOSIDES, *ANIMAL experimentation, *BIOLOGICAL models, *BLOOD sugar, *BODY weight, *CARRIER proteins, *CELLULAR signal transduction, *GESTATIONAL diabetes, *ENZYME-linked immunosorbent assay, *FETUS, *HERBAL medicine, *INSULIN, *CHINESE medicine, *MOTHERS, *PLACENTA, *PROTEIN kinases, *RATS, *TRANSFERASES, *WESTERN immunoblotting, *WEIGHT gain, *LEPTIN, *IN vivo studies, *DRUG administration, *DRUG dosage |
| مستخلص: |
Background: Gestational diabetes mellitus (GDM) is a type of diabetes associated with pregnancy and may impose risks on both mother and fetus. Akt paeoniflorin was shown to have anti-inflammatory and anti-hyperglycemia properties and has a potential ability to suppress mammalian target of rapamycin (mTOR) signaling. The current study aimed to study the effect of paeoniflorin on GDM maternal, fetal, and placental characteristics in vivo. Methods: Streptozotocin (STZ)-induced gestational diabetes rat model was used in our study. The expression levels of phosphorylation (p-) and total protein expression levels of protein kinase B (Akt), mTOR, serum/glucocorticoid regulated kinase 1 (SGK1), and eIF4E-binding protein 1 (4E-BP1) in the placenta were determined by Western blot assay. The blood glucose, insulin, and leptin levels were assessed using enzyme-linked immunosorbent assay (ELISA). Results: We found that placental Akt/mTOR signaling was substantially upregulated in GDM patients compared with healthy donors. Paeoniflorin administration alleviates the dysregulation of blood glucose, leptin, and insulin levels in both maternal and fetal GDM rats. Paeoniflorin treatment suppressed the overactivation of Akt/mTOR signaling in placental tissues. More importantly, administration of paeoniflorin was beneficial for normalization of fetal size and body weight in the GDM rats. Conclusion: Our study suggested that application of paeoniflorin may serve as a potential therapeutical strategy for patients with GDM. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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