التفاصيل البيبلوغرافية
| العنوان: |
High Percentage of IBD Patients with Indefinite Fecal Calprotectin Levels: Additional Value of a Combination Score. |
| المؤلفون: |
Bodelier, Alexander alexander.bodelier@home.nl, Jonkers, Daisy1, Heuvel, Tim1, Boer, Evelien1, Hameeteman, Wim1, Masclee, Ad1, Pierik, Marie1, Bodelier, Alexander G L2,3 (AUTHOR), van den Heuvel, Tim2 (AUTHOR), de Boer, Evelien2 (AUTHOR), Masclee, Ad A M2 (AUTHOR), Pierik, Marie J2 (AUTHOR) |
| المصدر: |
Digestive Diseases & Sciences. Feb2017, Vol. 62 Issue 2, p465-472. 8p. |
| مصطلحات موضوعية: |
*INFLAMMATORY bowel disease diagnosis, *C-reactive protein, *BIOMARKERS, *ENDOSCOPY, *CLINICAL trials, *COLONOSCOPY, *CROHN'S disease, *FECES, *INFLAMMATORY bowel diseases, *QUESTIONNAIRES, *ULCERATIVE colitis |
| مستخلص: |
Background and Aim: Monitoring mucosal inflammation in inflammatory bowel disease (IBD) is of major importance to prevent complications and improve long-term disease outcome. The correlation of clinical activity indices with endoscopic disease activity is, however, moderate. Fecal calprotectin (FC) is a better predictor of mucosal inflammation, but values between 100 and 250 µg/g are difficult to interpret in clinical practice. We aimed to evaluate the occurrence of indefinite FC levels in a real-life IBD cohort and study the additional value of a combination of biochemical markers and clinical activity indices.Methods: In total, 148 Crohn's disease (CD) and 80 ulcerative colitis (UC) patients visiting the outpatient clinic were enrolled. FC, clinical disease activity scored by the Harvey-Bradshaw index or Simple Clinical Colitis Activity Index, and C-reactive protein (CRP) were assessed. In a subset of patients, endoscopic activity was scored by the simple endoscopic score-Crohn's disease and Mayo endoscopic subscore. Clinical activity index, CRP, and FC were integrated in a combination score and compared with endoscopy.Results: Indefinite FC values were present in 24% of CD and 15% of UC. In the cohort of patients with endoscopy scores available, the combination score predicted endoscopic disease activity in CD with a sensitivity of 83% and specificity of 69% [positive predictive value (PPV) 58%, negative predictive value (NPV) 89%]. In UC, this was 88 and 75% (PPV 93%, NPV 60%).Conclusions: A combination of FC with clinical activity indices or CRP may aid in classifying patients with indefinite disease activity according to FC alone. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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