التفاصيل البيبلوغرافية
| العنوان: |
Vitamins B status and antioxidative defense in patients with chronic hepatitis B or hepatitis C virus infection. |
| المؤلفون: |
Lin, Chun-che, Liu, Wen-hu1, Wang, Zhi-hong2, Yin, Mei-chin mcyin@mail.cmu.edu.tw |
| المصدر: |
European Journal of Nutrition. Oct2011, Vol. 50 Issue 7, p499-506. 8p. 6 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*ANALYSIS of variance, *BIOMARKERS, *CHOLESTEROL, *CHRONIC diseases, *COMPARATIVE studies, *DIET, *FATTY acids, *FOLIC acid, *HEPATITIS B, *HEPATITIS C, *INFLAMMATION, *LACTATE dehydrogenase, *NUTRITIONAL assessment, *NUTRITIONAL requirements, *REGRESSION analysis, *VITAMIN B complex, *VITAMIN B2, *VITAMIN B6, *STATISTICAL significance, *OXIDATIVE stress, *GHRELIN, *FOOD diaries, *DATA analysis software |
| مصطلحات جغرافية: |
TAIWAN |
| مستخلص: |
Background & Aims: The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon B vitamins status and antioxidative defense in infected patients was examined. Methods: Dietary record and blood levels of B vitamins and oxidative stress-associated biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV patients. Results: HBV-infected patients had significantly higher levels of total cholesterol, free fatty acids (FFA), and lower ghrelin level ( p < 0.05); and HCV-infected patients had significantly higher Ishak inflammation score and lactate dehydrogenase activity ( p < 0.05). HBV patients had significantly lower red blood cell (RBC) vitamins B and B levels, and HCV infection significantly decreased vitamins B B and folate levels in RBC and/or plasma ( p < 0.05). Correlation coefficients of RBC vitamin B versus serum FFA in HBV patients, RBC vitamins B and B versus HCV RNA and Ishak inflammation score, and plasma vitamin B vs Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had significantly higher oxidized glutathione level and lower glutathione peroxidase activity ( p < 0.05), but HCV patients had significantly lower superoxide dismutase and catalase activities ( p < 0.05). Conclusion: HBV or HCV infection enhanced oxidative stress and lowered B vitamins in circulation. In order to avoid other healthy risk, nutrition status should be monitored and limitation or supplementation of certain nutrients might be helpful for HBV- or HCV-infected patients. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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