التفاصيل البيبلوغرافية
| العنوان: |
Signaling-dependent Phosphorylation of Mitotic Centromere-associated Kinesin Regulates Microtubule Depolymerization and Its Centrosomal Localization. |
| المؤلفون: |
Pakala, Suresh B.1, Nair, Vasudha S.1, DivijendraNatha Reddy, Sirigiri1, Kumar, Rakesh1 bcmrxk@gwu.edu |
| المصدر: |
Journal of Biological Chemistry. 11/23/2012, Vol. 287 Issue 48, p40560-40569. 10p. |
| مصطلحات موضوعية: |
*PHOSPHORYLATION, *CELL cycle, *CENTROMERE, *KINESIN, *MICROTUBULES, *POLYMERIZATION, *P21 gene, *KINASES |
| مستخلص: |
Although p21-activated kinase 1 (PAK1) and microtubule (MT) dynamics regulate numerous fundamental processes including cytoskeleton remodeling, directional motility, and mitotic functions, the significance of PAK1 signaling in regulating the functions of MT-destabilizing protein mitotic centromere- associated kinesin (MCAK) remains unknown. Here we found thatMCAKis a cognate substrate of PAK1 wherein PAK1 phosphorylates MCAK on serines 192 and 111 both in vivo and in vitro. Furthermore, we found that PAK1 phosphorylation of MCAKon serines 192 and 111 preferentially regulates its microtubule depolymerization activity and localization to centrosomes, respectively, in the mammalian cells. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder