التفاصيل البيبلوغرافية
| العنوان: |
Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors. |
| المؤلفون: |
Goldstein, Nathaniel B1, Koster, Maranke I2, Hoaglin, Laura G2, Spoelstra, Nicole S3, Kechris, Katerina J4, Robinson, Steven E5, Robinson, William A5, Roop, Dennis R2, Norris, David A2, Birlea, Stanca A1 |
| المصدر: |
Journal of Investigative Dermatology. Aug2015, Vol. 135 Issue 8, p2068-2076. 9p. |
| مصطلحات موضوعية: |
*VITILIGO, *THERAPEUTIC use of ultraviolet radiation, *CELL proliferation, *CELL migration, *MELANOCYTES, *AUTOIMMUNE diseases, *IMMUNOFLUORESCENCE, *THERAPEUTICS |
| مستخلص: |
In vitiligo, the autoimmune destruction of epidermal melanocytes produces white spots that can be repigmented by melanocyte precursors from the hair follicles, following stimulation with UV light. We examined by immunofluorescence the distribution of melanocyte markers (C-KIT, DCT, PAX3, and TYR) coupled with markers of proliferation (KI-67) and migration (MCAM) in precursors and mature melanocytes from the hair follicle and the epidermis of untreated and narrow band UVB (NBUVB)-treated human vitiligo skin. NBUVB was associated with a significant increase in the number of melanocytes in the infundibulum and with restoration of the normal melanocyte population in the epidermis, which was lacking in the untreated vitiligo. We identified several precursor populations (melanocyte stem cells, melanoblasts, and other immature phenotypes), and progressively differentiating melanocytes, some with putative migratory and/or proliferative abilities. The primary melanocyte germ was present in the untreated and treated hair follicle bulge, whereas a possible secondary melanocyte germ composed of C-KIT+ melanocytes was found in the infundibulum and interfollicular epidermis of UV-treated vitiligo. This is an exceptional model for studying the mobilization of melanocyte stem cells in human skin. Improved understanding of this process is essential for designing better treatments for vitiligo, ultimately based on melanocyte stem cell activation and mobilization. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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