التفاصيل البيبلوغرافية
| العنوان: |
HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism. |
| المؤلفون: |
Narayanan, Sampath1,2, Eliasson Angelstig, Sofie1,2, Xu, Cheng1,2, Grünler, Jacob1,2, Zhao, Allan1, Zhu, Wan3, Xu Landén, Ning4, Ståhle, Mona4, Zhang, Jingping5, Ivan, Mircea6, Maltesen, Raluca Georgiana7, Botusan, Ileana Ruxandra1,2, Rajamand Ekberg, Neda1,2, Zheng, Xiaowei1,2 Xiaowei.zheng@ki.se, Catrina, Sergiu-Bogdan1,2,8 Sergiu-Bogdan.Catrina@ki.se |
| المصدر: |
Communications Biology. 12/14/2020, Vol. 3 Issue 1, p1-11. 11p. |
| مصطلحات موضوعية: |
*CELL metabolism, *MOLECULAR dynamics, *MICROFLUIDICS, *MEMBRANE proteins, *SQUAMOUS cell carcinoma |
| مستخلص: |
Wound healing is a high energy demanding process that needs a good coordination of the mitochondria with glycolysis in the characteristic highly hypoxic environment. In diabetes, hyperglycemia impairs the adaptive responses to hypoxia with profound negative effects on different cellular compartments of wound healing. miR-210 is a hypoxia-induced microRNA that regulates cellular metabolism and processes important for wound healing. Here, we show that hyperglycemia blunted the hypoxia-dependent induction of miR-210 both in vitro and in human and mouse diabetic wounds. The impaired regulation of miR-210 in diabetic wounds is pathogenic, since local miR-210 administration accelerated wound healing specifically in diabetic but not in non-diabetic mice. miR-210 reconstitution restores the metabolic balance in diabetic wounds by reducing oxygen consumption rate and ROS production and by activating glycolysis with positive consequences on cellular migration. In conclusion, miR-210 accelerates wound healing specifically in diabetes through improvement of the cellular metabolism. Narayanan et al. show that local administration of miR-210 accelerates wound healing specifically in diabetic mice. They find that miR-210 restores the metabolic balance in diabetic wounds by activating glycolysis and cellular migration. This study presents miR-210 as a potential therapeutic option to treat diabetic wound healing. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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