التفاصيل البيبلوغرافية
| العنوان: |
The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice. |
| المؤلفون: |
Nishihara, Michihide1, Aoki, Hiroki2 haoki@med.kurume-u.ac.jp, Ohno, Satoko1, Furusho, Aya1, Hirakata, Saki1, Nishida, Norifumi1, Ito, Sohei1, Hayashi, Makiko1, Imaizumi, Tsutomu3, Fukumoto, Yoshihiro1 |
| المصدر: |
PLoS ONE. 10/05/2017, Vol. 12 Issue 10, p1-19. 19p. |
| مصطلحات موضوعية: |
*AORTIC aneurysms, *INTERLEUKIN-6, *MATRIX metalloproteinases, *CYTOKINES, *CELL motility |
| مستخلص: |
Although the pathogenesis of abdominal aortic aneurysm (AAA) remains unclear, evidence is accumulating to support a central role for inflammation. Inflammatory responses are coordinated by various soluble cytokines of which IL-6 is one of the major proinflammatory cytokines. In this study we examined the role of IL-6 in the pathogenesis of experimental AAA induced by a periaortic exposure to CaCl2 in mice. We now report that the administration of MR16-1, a neutralizing monoclonal antibody specific for the mouse IL-6 receptor, mildly suppressed the development of AAA. The inhibition of IL-6 signaling provoked by MR16-1 also resulted in a suppression of Stat3 activity. Conversely, no significant changes in either NFκB activity, Jnk activity or the expression of matrix metalloproteinases (Mmp) -2 and -9 were identified. Transcriptome analyses revealed that MR16-1-sensitive genes encode chemokines and their receptors, as well as factors that regulate vascular permeability and cell migration. Imaging cytometric analyses then consistently demonstrated reduced cellular infiltration for MR16-1-treated AAA. These results suggest that IL-6 plays an important but limited role in AAA pathogenesis, and primarily regulates cell migration and infiltration. These data would also suggest that IL-6 activity may play an important role in scenarios of continuous cellular infiltration, possibly including human AAA. [ABSTRACT FROM AUTHOR] |
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