التفاصيل البيبلوغرافية
| العنوان: |
Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure. |
| المؤلفون: |
Kmieciak, Maciej1, Payne, Kyle K.1, Idowu, Michael O.2, Grimes, Margaret M.2, Graham, Laura3, Ascierto, Maria-Libera4, Ena Wang4, Xiang-Yang Wang5, Bear, Harry D.3, Manjili, Masoud H.1 mmanjili@vcu.edu, Wang, Ena (AUTHOR), Wang, Xiang-Yang (AUTHOR) |
| المصدر: |
Journal of Translational Medicine. 2011, Vol. 9 Issue 1, p35-39. 5p. |
| مصطلحات موضوعية: |
*T cells, *CYSTS (Pathology), *ENZYME-linked immunosorbent assay, *IMMUNOHISTOCHEMISTRY, *PRECANCEROUS conditions, *BIOLOGICAL transport, *BREAST tumors, *CELL lines, *CELL nuclei, *CELL receptors, *IMMUNITY, *INTERFERONS, *DISEASE progression |
| مستخلص: |
Background: Emerging data from pre-clinical and clinical studies suggest that HER-2/neu-specific T cell responses could induce HER-2/neu antigen loss in the tumor cells. These data suggest that patients with HER-2/neu negative breast cancer might have had HER-2/neu positive premalignant lesions in the past that progressed to HER-2/neu negative breast cancer under HER-2/neu-specific immune pressure.Methods: We conducted a pilot study in patients with HER-2/neu positive and HER-2/neu negative breast cancers as well as a patient with ductal carcinoma in situ (DCIS). HER-2/neu expression was determined by FISH. HER-2/neu-specific T cell responses were determined by using IFN-γ ELISA. Expression of IFN-γ Rα in the tumors was determined by immunohistochemistry analysis of paraffin-embedded tissues.Results: We determined that majority of (10 of 12) patients with HER-2/neu negative breast cancer had HER-2/neu-specific IFN-γ producing T cell responses which was stronger than those in patients with HER-2/neu positive tumors. Such immune responses were associated with nuclear translocation of IFN-γ Rα in their tumor cells. Patient with DCIS also showed HER-2/neu-specific T cell responses.Conclusion: These data suggest that conducting retrospective studies in patients with HER-2/neu negative breast cancers and prospective studies in patients with HER-2/neu positive DCIS can determine whether HER-2/neu negative invasive carcinomas arise from HER-2/neu positive DCIS under the immune pressure. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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