التفاصيل البيبلوغرافية
| العنوان: |
Polyvinylpyrrolidone in hemodialysis membranes: Impact on platelet loss during hemodialysis. |
| المؤلفون: |
Zawada, Adam M.1 (AUTHOR) adam.zawada@fmc-ag.com, Melchior, Pascal1 (AUTHOR), Erlenkötter, Ansgar2 (AUTHOR), Delinski, Dirk1 (AUTHOR), Stauss‐Grabo, Manuela3 (AUTHOR), Kennedy, James P.1 (AUTHOR) |
| المصدر: |
Hemodialysis International. Oct2021, Vol. 25 Issue 4, p498-506. 9p. |
| مصطلحات موضوعية: |
*POVIDONE, *BLOOD platelets, *X-ray photoelectron spectroscopy, *ARTIFICIAL membranes |
| مستخلص: |
Introduction: Hydrophilic modification with polyvinylpyrrolidone (PVP) increases the biocompatibility profile of synthetic dialysis membranes. However, PVP may be eluted into the patient's blood, which has been discussed as a possible cause for adverse reactions rarely occurring with synthetic membranes. We investigated the content of PVP and its elution from the blood‐side surface from commercially available dialyzers, including the novel FX CorAL, with PVP‐enriched and α‐tocopherol‐stabilized membrane, and link the results to the level of platelet loss during dialysis as a maker of biocompatibility. Methods: Six synthetic, PVP containing, dialyzers (FX CorAL, FX CorDiax [Fresenius Medical Care]; Polyflux, THERANOVA [Baxter]; ELISIO [Nipro]; xevonta [B. Braun]) were investigated in the present study. The content of PVP on blood‐side surface was determined with X‐ray photoelectron spectroscopy (XPS). The amount of elutable PVP was measured photometrically after 5 h recirculation. The level of platelet loss was evaluated in an ex vivo recirculation model with human blood. Findings Highest PVP content on the blood‐side surface was found for the polysulfone‐based FX CorAL (26.3%), while the polyethersulfone‐based THERANOVA (15.6%) had the lowest PVP content. Elution of PVP was highest for the autoclave steam‐sterilized THERANOVA (9.1 mg/1.6 m2 dialyzer) and Polyflux (9.0 mg/1.6 m2 dialyzer), while the lowest PVP elution was found for the INLINE steam sterilized FX CorAL and FX CorDiax (<0.5 mg/1.6 m2 dialyzer, for both). Highest platelet loss was found for xevonta (+164.4% compared to the reference) and the lowest for the FX CorAL (−225.2%) among the polysulfone‐based dialyzers; among the polyethersulfone‐based dialyzers, THERANOVA (+95.5%) had the highest and ELISIO (−52.1%) the lowest platelet loss. Discussion Polyvinylpyrrolidone content and elution differ between commercially available dialyzers and were found to be linked to the membrane material and sterilization method. The amount of non‐eluted PVP on the blood‐side surface may be an important determinant for the biocompatibility of dialyzers. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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