التفاصيل البيبلوغرافية
| العنوان: |
Integrative Omics Approach Identifies Interleukin-16 as a Biomarker of Emphysema. |
| المؤلفون: |
Bowler, Russell P.1 Bowlerr@njhealth.org, Bahr, Timothy M.2, Hughes, Grant2, Lutz, Sharon2, Yu-Il Kim3, Coldren, Christopher D.4, Reisdorph, Nichole5, Kechris, Katerina J.2 |
| المصدر: |
OMICS: A Journal of Integrative Biology. Dec2013, Vol. 17 Issue 12, p619-626. 8p. |
| مصطلحات موضوعية: |
*INTERLEUKIN-16, *OBSTRUCTIVE lung diseases, *ALLERGY treatment, *HUMAN missense mutation, *GENE expression, *MULTIVARIATE analysis, *GENETICS |
| مستخلص: |
Interleukin-16 (IL-16) is a multifunctional cytokine that has been associated with autoimmune and allergic diseases. To investigate comprehensively whether IL-16 is also associated with chronic obstructive pulmonary disease (COPD) and emphysema, we performed an integrated analysis of multiple "omics" data. Over 500 subjects participating in the COPDGene® study donated blood and were clinically characterized and genetically profiled. IL-16 mRNA levels were measured in peripheral blood mononuclear cells (PBMC), and protein levels were measured in fresh frozen plasma. A multivariate analysis found plasma IL-16 positively associated with age and body mass index, and negatively associated with current smoking and emphysema in the upper lobes. PBMC IL-16 expression was positively associated with gender and a composite score for airflow obstruction, emphysema, and gas trapping. Whole-genome expression quantitative trait locus (eQTL) analysis identified a novel IL-16 missense SNP (rs11556218) associated with lower IL-16 in plasma. In summary, an integrated "omics" analysis in a very large cohort identified an association between decreased IL-16 and emphysema and discovered a novel IL-16 cis-eQTL. Thus IL-16 plasma levels and IL-16 genotyping may be useful in a personalized medicine approach for lung disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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