المؤلفون: Sińska, Beata I.¹ (AUTHOR) alicja.kucharska@wum.edu.pl, Rzońca, Ewa² (AUTHOR) erzonca@wum.edu.pl, Kucharska, Alicja¹ (AUTHOR) iwona.traczyk@wum.edu.pl, Gałązkowski, Robert³ (AUTHOR) robert.galazkowski@wum.edu.pl, Traczyk, Iwona¹ (AUTHOR), Rzońca, Patryk⁴ (AUTHOR) patryk.rzonca@wum.edu.pl

المصدر: European Journal of Investigation in Health, Psychology & Education (EJIHPE). Oct2023, Vol. 13 Issue 10, p2035-2045. 11p.

مصطلحات موضوعية: *GLYCOSYLATED hemoglobin, *TYPE 1 diabetes, *GLYCEMIC control, *DIABETES, *ADULTS, *COMPULSIVE eating

مستخلص: Numerous complications of type 1 diabetes (T1D) may be prevented through suitable glycemic control. Glycated hemoglobin (HbA1c) may be one of the markers for the early detection of the metabolic imbalance characteristic of the disease. However, optimal control of diabetes is not achieved in a large group of patients. It was demonstrated that numerous factors (sociodemographic, psychological, and clinical) contributed to this condition. The aim of the study was to identify factors influencing the control of diabetes measured via glycated hemoglobin concentrations in people with T1D. Independent factors influencing better diabetes control measured via HbA1c in the study group included higher disease acceptance, higher nutritional adherence, lower BMI, and a lower risk of eating disorders. Describing the determinants will allow for the improvement of the system of care provided to people with T1D and for it to comprise important psychological variables related to self-care and acceptance of the disease. [ABSTRACT FROM AUTHOR]

المؤلفون: Kruger, Davida¹ (NURSE), Kass, Alex² (NURSE), Lonier, Jacqueline³ (AUTHOR), Pettus, Jeremy⁴ (AUTHOR), Raskin, Philip⁵ (AUTHOR), Salam, Maamoun⁶ (AUTHOR), Trikudanathan, Subbulaxmi⁷ (AUTHOR), Zhou, Keren⁸ (AUTHOR), Russell, Steven J.⁹ (AUTHOR), Damiano, Edward R.^10,11 (AUTHOR), El-Khatib, Firas H.¹¹ (AUTHOR), Ruedy, Katrina J.¹² (AUTHOR), Balliro, Courtney⁹ (AUTHOR), Li, Zoey¹² (AUTHOR), Marak, Martin Chase¹² (AUTHOR), Calhoun, Peter¹² (AUTHOR), Beck, Roy W.¹² (AUTHOR) rbeck@jaeb.org

المصدر: Diabetes Technology & Therapeutics. Oct2022, Vol. 24 Issue 10, p697-711. 15p.

مصطلحات موضوعية: *TYPE 1 diabetes, *INSULIN aspart, *CLOSED loop systems, *BIONICS, *PANCREAS

مستخلص: Objective: To evaluate the insulin-only configuration of the iLet® bionic pancreas (BP) using insulin aspart or insulin lispro in adults with type 1 diabetes (T1D). Methods: In this multicenter, randomized, controlled trial, 161 adults with T1D (18-79 years old, baseline HbA1c 5.5%-13.1%, 32% using multiple daily injections, 27% using a pump without automation, 5% using a pump with predictive low glucose suspend, and 36% using a hybrid closed loop system before the study) were randomly assigned 2:1 to use the BP (N = 107) with insulin aspart or insulin lispro (BP group) or a standard-of-care (SC) control group (N = 54) using their usual insulin delivery plus continuous glucose monitoring (CGM). The primary outcome was HbA1c at 13 weeks. Results: Mean HbA1c decreased from 7.6% ± 1.2% at baseline to 7.1% ± 0.6% at 13 weeks with BP versus 7.6% ± 1.2% to 7.5% ± 0.9% with SC (adjusted difference = -0.5%, 95% confidence interval -0.6% to -0.3%, P < 0.001). Over 13 weeks, mean time in range 70-180 mg/dL (TIR) increased by 11% (2.6 h/d) and mean CGM glucose was reduced by 16 mg/dL with BP compared with SC (P < 0.001). Improvement in these metrics was seen during the first day of BP use and by the end of the first week reached levels that remained relatively stable through 13 weeks. Analyses of time >180 mg/dL, time >250 mg/dL, and standard deviation of CGM glucose all favored the BP group (P < 0.001). The CGM-measured hypoglycemia was low at baseline (median time <54 mg/dL of 0.21% [3 min/d] for the BP group and 0.11% [1.6 min/d] for the SC group) and not significantly different between groups over the 13 weeks (P = 0.51 for time <70 mg/dL and 0.33 for time <54 mg/dL). There were 7 (6.5% of 107 participants) severe hypoglycemic events in the BP group and 2 events in the SC group (1.9% of 54 participants, P = 0.40). Conclusions: In adults with T1D, use of the BP with insulin aspart or insulin lispro improved HbA1c, TIR, and hyperglycemic metrics without increasing CGM-measured hypoglycemia compared with standard of care. Clinical Trial Registry: clinicaltrials.gov; NCT04200313. [ABSTRACT FROM AUTHOR]

المؤلفون: Beck, Roy W.¹ (AUTHOR) rbeck@jaeb.org, Russell, Steven J.² (AUTHOR), Damiano, Edward R.^3,4 (AUTHOR), El-Khatib, Firas H.⁴ (AUTHOR), Ruedy, Katrina J.¹ (AUTHOR), Balliro, Courtney² (NURSE), Li, Zoey¹ (AUTHOR), Calhoun, Peter¹ (AUTHOR)

المصدر: Diabetes Technology & Therapeutics. Oct2022, Vol. 24 Issue 10, p681-696. 16p.

مصطلحات موضوعية: *INSULIN aspart, *TYPE 1 diabetes, *BIONICS, *PANCREAS, *INSULIN therapy

مستخلص: Objective: To evaluate the insulin-only configuration of the iLet® bionic pancreas (BP) using fast-acting insulin aspart (Fiasp®) in adults with type 1 diabetes (T1D). Research Design and Methods: In this multicenter, randomized trial, 275 adults with T1D (18–83 years old, baseline HbA1c 5.3%–14.9%) were randomly assigned 2:2:1 to use the BP with fast-acting insulin aspart (BP-F group, N = 114), BP with aspart or lispro (BP-A/L group, N = 107), or a control group using their standard-care insulin delivery (SC group, N = 54) plus real-time continuous glucose monitoring (CGM). The primary outcome was HbA1c at 13 weeks. The BP-F versus SC comparison was considered primary and BP-F versus BP-A/L secondary. Results: Mean ± standard deviation (SD) HbA1c decreased from 7.8% ± 1.2% at baseline to 7.1% ± 0.6% at 13 weeks with BP-F versus 7.6% ± 1.2% to 7.5% ± 0.9% with SC (adjusted difference = −0.5%, 95% CI −0.7 to −0.3, P < 0.001). CGM-measured percent time <54 mg/dL over 13 weeks with BP-F was noninferior to SC (adjusted difference = 0.00%, 95% CI −0.07 to 0.05, P < 0.001 for noninferiority based on a prespecified noninferiority limit of 1%). Over 13 weeks, mean time in range 70–180 mg/dL (TIR) increased by 14% (3.4 h/day) and mean CGM glucose was reduced by 18 mg/dL with BP-F compared with SC (P < 0.001). Analyses of time >180 mg/dL, time >250 mg/dL, and the SD of CGM glucose all favored BP-F compared with SC (P < 0.001). Differences between BP-F and BP-A/L were minimal, with no difference in HbA1c at 13 weeks (adjusted difference = −0.0%, 95% CI −0.2 to 0.1, P = 0.67) or mean glucose (adjusted difference = −2.0 mg/dL, 95% CI −4.3 to 0.4, P = 0.10). Mean TIR was 2% greater with BP-F than BP-A/L (95% CI 1 to 4, P = 0.005), but the percentages of participants improving TIR by ≥5% were not significantly different (P = 0.49) and there were no significant differences comparing BP-F versus BP-A/L across nine patient-reported outcome surveys. The rate of severe hypoglycemia events did not differ among the three groups. Conclusions: In adults with T1D, HbA1c was improved with the BP using fast-acting insulin aspart compared with standard care without increasing CGM-measured hypoglycemia. However, the effect was no better than the reduction observed with the BP using aspart or lispro. Clinical Trial Registry: clinicaltrials.gov; NCT04200313. [ABSTRACT FROM AUTHOR]

المؤلفون: Levy, Carol J.¹ (AUTHOR), O'Malley, Grenye¹ (AUTHOR), Raghinaru, Dan² (AUTHOR), Kudva, Yogish C.³ (AUTHOR), Laffel, Lori M.^4,5 (AUTHOR), Pinsker, Jordan E.⁶ (AUTHOR), Lum, John W.² (AUTHOR) jl_manuscripts@jaeb.org, Brown, Sue A.⁷ (AUTHOR), Kovatchev, Boris (AUTHOR), Anderson, Stacey (AUTHOR), Emory, Emma (AUTHOR), Voelmle, Mary (AUTHOR), Conshafter, Katie (AUTHOR), Morris, Kim (AUTHOR), Oliveri, Mary (AUTHOR), Gondor-Fredrick, Linda (AUTHOR), Mitchell, Harry (AUTHOR), Calvo, Kayla (AUTHOR), Wakeman, Christian (AUTHOR), Breton, Marc (AUTHOR)

المصدر: Diabetes Technology & Therapeutics. May2022, Vol. 24 Issue 5, p357-361. 5p.

مصطلحات موضوعية: *MENSTRUAL cycle, *TYPE 1 diabetes, *INSULIN, *GLYCEMIC control, *GLUCOSE, *BLOOD sugar analysis, *INSULIN therapy, *BLOOD sugar monitoring, *HYPOGLYCEMIC agents, *INSULIN pumps, *RESEARCH funding

مستخلص: Objective: To analyze insulin delivery and glycemic metrics throughout the menstrual cycle for women with type 1 diabetes using closed loop control (CLC) insulin delivery. Methods: Menstruating women using a CLC system in a clinical trial were invited to record their menstrual cycles through a cycle-tracking application. Sixteen participants provided data for this secondary analysis over three or more complete cycles. Insulin delivery and continuous glucose monitoring (CGM) data were analyzed in relation to reported cycle phases. Results: Insulin delivery and CGM metrics remained consistent during cycle phases. Intraparticipant variability of CGM metrics and weight-based insulin delivery did not change through cycle phases. Conclusions: For this sample of menstruating women with type 1 diabetes using a CLC system, insulin delivery and glycemic metrics remained stable throughout menstrual cycle phases. Additional studies in this population are needed, particularly among women who report variable glycemic control during their cycles. Trial Registration: NCT03591354. [ABSTRACT FROM AUTHOR]

المؤلفون: Carreon, Samantha A.¹ sxcarreo@texaschildrens.org, Cao, Viena T.¹, Anderson, Barbara J.¹, Thompson, Deborah I.^1,2, Marrero, David G.³, Hilliard, Marisa E.¹

المصدر: Diabetic Medicine. May2022, Vol. 39 Issue 5, p1-11. 11p.

مصطلحات موضوعية: *RESEARCH methodology, *TYPE 1 diabetes, *INTERVIEWING, *SLEEP disorders, *QUALITATIVE research, *THEMATIC analysis, *PSYCHOLOGICAL distress, *DISEASE complications

مصطلحات جغرافية: UNITED States

مستخلص: Aims: Individuals with type 1 diabetes (T1D) experience greater sleep disturbances than people without diabetes. However, the nature, causes and effects of sleep disruption in individuals with T1D and their family are not well understood. The purpose of this study was to explore and characterise the perspectives of parents, partners and individuals with diabetes about T1D‐related sleep issues. Methods: Participants included 44 youth and adults with T1D (ages 9–69), 24 parents of youth with T1D, and 14 partners of adults with T1D, recruited from diabetes clinics at two academic medical centres in the Southwestern and Midwestern United States. Semi‐structured qualitative interviews were transcribed verbatim, coded and analysed using hybrid thematic analysis. Results: We identified two central themes: Emotional Distress and Sleep Disruption. Each theme had multiple subthemes, and the two central themes were related to one another via a shared subtheme, Worry Impacting Sleep. Conclusions: Complex T1D‐related emotional and behavioural factors both contributed to and resulted from sleep difficulties. Diabetes care providers should routinely assess for sleep concerns in people with T1D and their parents and partners. It may be important to consider both diabetes‐related causes of sleep disruptions and potential impacts on self management and emotional functioning. [ABSTRACT FROM AUTHOR]

المؤلفون: Qianwen Huang¹, Daizhi Yang¹, Hongrong Deng¹, Hua Liang¹, Xueying Zheng², Jinhua Yan¹, Wen Xu¹, Xiangwen Liu¹, Bin Yao¹, Sihui Luo² luosihui@ustc.edu.cn, Jianping Weng^1,2

المصدر: Diabetes & Metabolism Journal. Jan2022, Vol. 46 Issue 1, p93-103. 14p.

مصطلحات موضوعية: *TYPE 1 diabetes, *DIABETIC retinopathy, *GLYCOSYLATED hemoglobin, *METABOLIC syndrome, *DIABETIC nephropathies, *ADULTS, *INSULIN pumps

مصطلحات جغرافية: CHINA

مستخلص: Background: Both type 1 diabetes mellitus (T1DM) and metabolic syndrome (MetS) are associated with an elevated risk of morbidity and mortality yet with increasing heterogeneity. This study primarily aimed to evaluate the prevalence of MetS among adult patients with T1DM in China and investigate its associated risk factors, and relationship with microvascular complications. Methods: We included adult patients who had been enrolled in the Guangdong T1DM Translational Medicine Study conducted from June 2010 to June 2015. MetS was defined according to the updated National Cholesterol Education Program criterion. Logistic regression models were used to estimate the odds ratio (OR) for the association between MetS and the risk of diabetic kidney disease (DKD) and diabetic retinopathy (DR). Results: Among the 569 eligible patients enrolled, the prevalence of MetS was 15.1%. While female gender, longer diabetes duration, higher body mass index, and glycosylated hemoglobin A1c (HbA1c) were risk factors associated with MetS (OR, 2.86, 1.04, 1.14, and 1.23, respectively), received nutrition therapy education was a protective factor (OR, 0.46). After adjustment for gender, age, diabetes duration, HbA1c, socioeconomic and lifestyle variables, MetS status was associated with an increased risk of DKD and DR (OR, 2.14 and 3.72, respectively; both P<0.05). Conclusion: Although the prevalence of MetS in adult patients with T1DM in China was relatively low, patients with MetS were more likely to have DKD and DR. A comprehensive management including lifestyle modification might reduce their risk of microvascular complications in adults with T1DM. [ABSTRACT FROM AUTHOR]

المؤلفون: Rai, Seema¹ seemadoc98@yahoo.co.uk, Kaul, Varun¹, Singh, Sulena², Kaur, Savneet¹, Thenmurugan, Palani¹

المصدر: Oman Medical Journal. Jan2022, Vol. 37 Issue 1, p4-7. 4p.

مصطلحات موضوعية: *ANTHROPOMETRY, *TYPE 1 diabetes, *MOVEMENT disorders

الشركة/الكيان: CENTERS for Disease Control & Prevention (U.S.)

مستخلص: Diabetic striatopathy is a neurological condition in patients with diabetes characterized by hemichorea-hemiballismus due to vascular and metabolic derangements in basal ganglia. This is a known entity in type 2 diabetic adult patients; however, seen rarely in pediatric patients with type 1 diabetes. Diabetic striatopathy develops in patients with poor glycemic control in the absence of ketosis. The patient tolerates hyperglycemia for a long time, which results in metabolic injury. [ABSTRACT FROM AUTHOR]

المؤلفون: Al-Hadhrami, Rajaa¹ rajaa@squ.edu.om, Al-Rawajfah, Omar², Muliira, Joshua³

المصدر: Sultan Qaboos University Medical Journal. Nov2020, Vol. 20 Issue 4, pe339-e345. 7p.

مصطلحات موضوعية: *TYPE 1 diabetes, *GLYCEMIC control, *MEDICAL personnel, *MULTIPLE regression analysis, *DIABETES

مصطلحات جغرافية: OMAN

مستخلص: Objectives: This study aimed to assess and explore factors affecting diabetes self-management (DSM) among Omani adults with type one diabetes mellitus (T1DM). Methods: This cross-sectional study was conducted from May to November 2018. Convenience sampling was used to recruit participants from three referral hospitals in Oman. Data were collected using the Diabetes Self-Management Questionnaire, Empowerment Scale (short form), Medical Outcome Study Social Support Scale, Diabetes Knowledge Test and glycosylated haemoglobin test results. Linear multiple regression analysis was used to explore possible predictors of DSM. Results: A total of 210 people participated in the study (response rate: 87.5%). The majority of participants were female (70.5%) with a mean age of 26.82 ± 8.25 years. The mean score for DSM was 6.8 ± 1.4, which represents 68% of the total maximum score. More than one-third (36.2%) of the participants had poor glycaemic control. The predictors of high levels of DSM were being employed (P = 0.049), earning a low monthly income of less than 300 Omani rials (P = 0.014), having other chronic diseases (P = 0.029), a high diabetes self-efficacy (DSE; P = 0.003) and high social support (SS; P = 0.006). Conclusion: According to the findings of this study, Omanis with T1DM have suboptimal DSM levels. Factors such as diabetes knowledge, DSE and SS are modifiable factors that can be targeted by interventions from different healthcare professionals to enhance DSM. [ABSTRACT FROM AUTHOR]

المؤلفون: Al-Shuwaikh, Arwa Mujahid Abdullah¹ arwa.mujahid@colmed-alnahrain.edu.iq, Hanna, Dalya Basil², Ali, Zahraa Qasim³

المصدر: Journal of Pure & Applied Microbiology. Jun2019, Vol. 13 Issue 2, p1017-1023. 7p.

مصطلحات موضوعية: *HERPES simplex virus, *HUMAN herpesvirus 1, *BLOOD donors, *SEROPREVALENCE, *AGE groups

مصطلحات جغرافية: IRAQ, BAGHDAD (Iraq)

مستخلص: Herpes simplex virus type 1 (HSV-1) is a common infectious agent worldwide. It can cause earnest illnesses at each stage of life. Data on seroprevalence of HSV-1 antibody (Ab) in Iraqi population is limited. This study aimed on determination the frequency of HSV-1 IgG Ab in apparently healthy blood donor of Baghdad province, capital of Iraq. In this study, serum samples were collected from 454 apparently healthy blood donor (385 male and 69 female), their ages ranged from 18 to 64 year. This study was conducted through the period from October, 2018 to February, 2019. Demographic data were gathered by a well-designed questionnaire. Five (5) ml of blood sample was collected and centrifuged, all obtained sera samples were tested using Enzyme linked Immunosorbent Assay (ELISA) for determine of HSV-1 IgG Ab. Totally, HSV-1 IgG Ab were positive in 427 out of 454 (94.1%) among studied population. The age groups of (21-30) years and (31-40) years had the highest percentage of seropositivity for anti HSV-1 IgG Ab (39.1% and 32.3%, respectively), while the lowest seropositivity was found in age groups (>50) years and (=20) years (4.4% and 5.4%, respectively). The frequency of HSV-1 IgG Ab was higher among male (84.8%) compared with females (15.2%), however, it was not statistically significant (P > 0.05). Results confirm a high frequency of anti HSV-1 IgG Ab among Iraqi population. The high frequency of HSV-1 infection underlines the need for focusing on preventive efforts and education among the population about HSV-1 and its complications. [ABSTRACT FROM AUTHOR]

المؤلفون: Joensen, Lene E.¹ ljoe@steno.dk, Filges, Tine², Willaing, Ingrid¹

المصدر: Patient Preference & Adherence. Aug2016, Vol. 10, p1443-1451. 9p.

مصطلحات موضوعية: *TYPE 1 diabetes, *SOCIAL support, *PSYCHOSOCIAL factors, *SOCIAL capital, *PEOPLE with diabetes, *ATTITUDE (Psychology)

مستخلص: Aim: To explore the function of peer support from the perspective of adults with type 1 diabetes in Denmark. Methods: The study population consisted of 20 adults with type 1 diabetes. The sample was diverse in relation to educational background, age, sex, and cohabitation status. Inspired by action research, several methods and perspectives on peer support were explored and tested. Workshops and group and individual interviews were performed. Systematic text condensation was used to analyze data, supplemented with theory-based interpretive analysis. Results: Adults with type 1 diabetes found peer support highly relevant to reduce a burdensome feeling of diabetes-specific loneliness. Peer support showed potential to create diabetes-specific social capital not only by creating reciprocal social support between peers but also, more importantly, by creating space for genuine trust and a feeling of communality. There was a widespread feeling of the pervasive impact of diabetes on daily life and thus the relevance of discussing all aspects of life. However, participants perceived peer support as particularly relevant in relation to big changes in life, for example, in family life, at work, or through treatment events such as getting an insulin pump. Conclusion: Peer support programs focusing on creating and establishing diabetes-specific social capital using participatory approaches seem highly relevant among adults with type 1 diabetes. Content, methods, and effects of peer support need further exploration in collaboration with adults with type 1 diabetes. [ABSTRACT FROM AUTHOR]