التفاصيل البيبلوغرافية
| العنوان: |
The in vivo performance of a novel thermal accelerant agent used for augmentation of microwave energy delivery within biologic tissues during image-guided thermal ablation: a porcine study. |
| المؤلفون: |
Park, William Keun Chan1 (AUTHOR) William_Keun_Chan_Park@brown.edu, Maxwell, Aaron Wilhelm Palmer1 (AUTHOR), Frank, Victoria Elizabeth1 (AUTHOR), Primmer, Michael Patrick1 (AUTHOR), Paul, Jarod Brian1 (AUTHOR), Collins, Scott Andrew1 (AUTHOR), Lombardo, Kara Anne2 (AUTHOR), Lu, Shaolei2 (AUTHOR), Borjeson, Tiffany Marie3 (AUTHOR), Baird, Grayson Luderman1 (AUTHOR), Dupuy, Damian Edward1 (AUTHOR) |
| المصدر: |
International Journal of Hyperthermia. Feb2018, Vol. 34 Issue 1, p11-18. 8p. |
| مصطلحات موضوعية: |
*ABLATION techniques, *PERFUSION, *MAGNETIC resonance angiography, *SKELETAL muscle physiology, *LABORATORY swine |
| مستخلص: |
Objectives:To investigate the effects of a novel caesium-based thermal accelerant (TA) agent on ablation zone volumes followingin vivomicrowave ablation of porcine liver and skeletal muscle, and to correlate the effects of TA with target organ perfusion. Materials and methods:This prospective study was performed following institutional animal care and use committee approval. Microwave ablation was performed in liver and resting skeletal muscle in eightSus scrofa domesticusswine following administration of TA at concentrations of 0 mg/mL (control), 100 mg/mL and 250 mg/mL. Treated tissues were explanted and stained with triphenyltetrazolium chloride (TTC) for quantification of ablation zone volumes, which were compared between TA and control conditions. Hematoxylin and eosin (H&E) staining was also performed for histologic analysis. General mixed modelling with a log-normal distribution was used for all quantitative comparisons (p = 0.05). Results:A total of 28 ablations were performed in the liver and 18 in the skeletal muscle. The use of TA significantly increased ablation zone volumes in a dose-dependent manner in both the porcine muscle and liver (p < 0.01). Both the absolute mean ablation zone volume and percentage increase in ablation zone volume were greater in the resting skeletal muscle than in the liver. In one swine, a qualitative mitigation of heat sink effects was observed by TTC and H&E staining. Non-lethal polymorphic ventricular tachycardia was identified in one swine, treated with intravenous amiodarone. Conclusions:The use of a novel TA agent significantly increased mean ablation zone volumes following microwave ablation using a porcine model. The relationship between TA administration and ablation size was dose-dependent and inversely proportional to the degree of target organ perfusion, and a qualitative reduction in heat-sink effects was observed. [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
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