التفاصيل البيبلوغرافية
| العنوان: |
HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies. |
| المؤلفون: |
Yonghua Zhang, Taylor, Cynthia Quan, Dong, Michael W. |
| المصدر: |
LC-GC North America. Oct2014, Vol. 32 Issue 10, p796-808. 11p. |
| مصطلحات موضوعية: |
*HIGH performance liquid chromatography, *THERAPEUTIC use of monoclonal antibodies, *GEL permeation chromatography, *MOLECULAR size, *AFFINITY chromatography |
| مستخلص: |
The author discusses the use of High performance liquid chromatography (HPLC) modes for characterization and quality control of Monoclonal antibody (mAb) therapeutics. Topics discussed include use of size-exclusion chromatography (SEC) to separates molecules based on their molecular size, affinity chromatography that utilizes biologically based binding interaction to capture specific antibody molecules and complementary techniques that are used to expose minor changes to the mAb. |
| قاعدة البيانات: |
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