المؤلفون: Abdulla, Sara A.¹ sara.abdulla@uob.edu.ly, Elamami, Adela H.², Elawamy, Hayam³, Muhammed, Aisha A.⁴

المصدر: Ibnosina Journal of Medicine & Biomedical Sciences. Sep2020, Vol. 12 Issue 3, p185-194. 10p.

مصطلحات موضوعية: *COVID-19, *LACTATE dehydrogenase, *ASYMPTOMATIC patients, *BIOMARKERS, *C-reactive protein

مستخلص: Objectives: We aimed to analyze the laboratory data of coronavirus disease 2019 (COVID-19) patients for clinical help, to overcome the vulnerabilities of reverse transcription–polymerase chain reaction testing for diagnosing COVID-19, and to reduce the number of negative results when diagnosing, particularly in global regions which are recognized to have limited resources. Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the authors performed a systematic literature review, using three databases to assess laboratory data of COVID-19-confirmed cases, and the articles that described significant laboratory irregularities were ultimately chosen. Crosschecking was performed on the references of these articles in order to identify further studies. The statistical software R version 3.6.1 was used for meta-analysis of COVID-19 studies. Results: A total of 13 relevant articles were included. They yielded a total of 2662 individuals who tested positive for COVID-19. The analysis results demonstrated that male patients comprised a more substantial proportion, accounting for 57.9% of the total. The principal laboratory findings of the COVID-19 patients indicated that they commonly had lymphocytopenia 0.943 (confidence interval [CI]: 0.857–1.03), high D-dimer 0.459 (CI: 0.237–0.6808), high procalcitonin 0.089 (CI: 0.066–0.111), high C-reactive protein 17.203 (CI: 6.520–27.886), and high lactate dehydrogenase 278.265 (CI: 238.995–317.535). Conclusions: Infection with COVID-19 is associated with significant laboratory irregularities. The increased focus must be applied to laboratory parameters to quickly identify a large number of infected patients and asymptomatic carriers, prevent virus transmission, and assure timely treatment of patients, particularly in regions characterized by limited resources. [ABSTRACT FROM AUTHOR]

المؤلفون: Bhardwaj, Mohit^1,2 (AUTHOR) lucky.tonu@gmail.com, Arora, Bhavinder² (AUTHOR)

المصدر: Indian Journal of Neurosurgery. 2019, Vol. 8 Issue 2, p99-102. 4p.

مصطلحات موضوعية: *LACTATE dehydrogenase, *HEAD injuries, *SERUM, *CEREBROSPINAL fluid, *BRAIN damage

مستخلص: In recent years, some encouraging reports have appeared on assessing the degree of brain damage by estimating serum and cerebrospinal fluid enzymes such as lactate dehydrogenase (LDH). In our study, we included 100 patients with isolated head injury arriving at trauma center, PGIMS Rohtak within 24 hours of injury, studied levels of serum LDH on days 1, 3, and 7 of injury, and concluded that levels have diagnostic as well as prognostic significance. [ABSTRACT FROM AUTHOR]

المؤلفون: Jahan, S. K. Kousar¹ skkousar@yahoo.com, Mayanna, Mangala Gowri², Kavitha, B. L.², Patil, Akkamahadevi², Kumari, Prasanna²

المصدر: Indian Journal of Medical & Paediatric Oncology. Jan-Mar2014, Vol. 35 Issue 1, p89-92. 4p.

مصطلحات موضوعية: *CYTOGENETICS, *IMMUNOHISTOCHEMISTRY, *LACTATE dehydrogenase, *SYNAPTOPHYSIN, *MAGNETIC resonance imaging

مستخلص: Cytogenetic or immunohistochemical studies are often required to differentiate Ewing's sarcoma (ES) from other small round cell tumors. Herein we report a case of 13-year-old boy who presented with a large presacral lesion. Hemogram and biochemical parameters were normal except lactate dehydrogenase showing value of 96.40/IU/L, magnetic resonance imaging of the spine showed a large mass in presacral lesion (8 cm × 7 cm × 9 cm), with destruction of the sacrum (S2 S3 and S4) with interspinal extension. Bone scan showed multiple pelvic bone lesions, radiograph of chest, ultrasound of abdomen, pelvis and electrocardiogram were within normal limits. Bone marrow was not involved. Cells from the fine needle aspirate were cultured for short term using RPMI medium and karyotype obtained showed a t(12;22)(p12;q12) instead of the classic t(11;22). Diagnosis of ES was also confirmed by studies using immunohistochemistry for MIC2 which was positive, synaptophysin was inconclusive and leukocyte common antigen, desmin negative. This case provides evidence of the importance of chromosome 22, in the etiology of the disease. [ABSTRACT FROM AUTHOR]

المؤلفون: Abdulla, Sara A.¹ sara.abdulla@uob.edu.ly, Elamami, Adela H.², Elawamy, Hayam³, Muhammed, Aisha A.⁴

المصدر: Ibnosina Journal of Medicine & Biomedical Sciences. Jul-Sep2020, Vol. 12 Issue 3, p185-194. 10p.

مصطلحات موضوعية: *COVID-19, *META-analysis, *BIOMARKERS, *LACTATE dehydrogenase, *C-reactive protein

مستخلص: Objectives: We aimed to analyze the laboratory data of coronavirus disease 2019 (COVID-19) patients for clinical help, to overcome the vulnerabilities of reverse transcription-polymerase chain reaction testing for diagnosing COVID-19, and to reduce the number of negative results when diagnosing, particularly in global regions which are recognized to have limited resources. Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the authors performed a systematic literature review, using three databases to assess laboratory data of COVID-19-confirmed cases, and the articles that described significant laboratory irregularities were ultimately chosen. Crosschecking was performed on the references of these articles in order to identify further studies. The statistical software R version 3.6.1 was used for meta-analysis of COVID-19 studies. Results: A total of 13 relevant articles were included. They yielded a total of 2662 individuals who tested positive for COVID-19. The analysis results demonstrated that male patients comprised a more substantial proportion, accounting for 57.9% of the total. The principal laboratory findings of the COVID-19 patients indicated that they commonly had lymphocytopenia 0.943 (confidence interval [CI]: 0.857-1.03), high D-dimer 0.459 (CI: 0.237-0.6808), high procalcitonin 0.089 (CI: 0.066-0.111), high C-reactive protein 17.203 (CI: 6.520-27.886), and high lactate dehydrogenase 278.265 (CI: 238.995-317.535). Conclusions: Infection with COVID-19 is associated with significant laboratory irregularities. The increased focus must be applied to laboratory parameters to quickly identify a large number of infected patients and asymptomatic carriers, prevent virus transmission, and assure timely treatment of patients, particularly in regions characterized by limited resources. [ABSTRACT FROM AUTHOR]

المؤلفون: Das, Karuna M.^1,2 daskmoy@gmail.com, Lee, Edward Y.³, Singh, Rajvir⁴, Enani, Mushira A.⁵, Dossari, Khalid Al², Van Gorkom, Klaus¹, Larsson, Sven G.², Langer, Ruth D.¹

المصدر: Indian Journal of Radiology & Imaging. Jul-Sep2017, Vol. 27 Issue 3, p342-349. 8p.

مصطلحات موضوعية: *CHEST X rays, *CONVALESCENCE, *PATIENT aftercare, *LACTATE dehydrogenase, *LYMPHATIC diseases, *PLEURAL effusions, *PNEUMOTHORAX, *PULMONARY fibrosis, *T-test (Statistics), *MERS coronavirus, *MANN Whitney U Test

مستخلص: Purpose: To evaluate the follow-up chest radiographic findings in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) who were discharged from the hospital following improved clinical symptoms. Materials and Methods: Thirty-six consecutive patients (9 men, 27 women; age range 21-73 years, mean ± SD 42.5 ± 14.5 years) with confirmed MERS-CoV underwent follow-up chest radiographs after recovery from MERS-CoV. The 36 chest radiographs were obtained at 32 to 230 days with a median follow-up of 43 days. The reviewers systemically evaluated the follow-up chest radiographs from 36 patients for lung parenchymal, airway, pleural, hilar and mediastinal abnormalities. Lung parenchyma and airways were assessed for consolidation, ground-glass opacity (GGO), nodular opacity and reticular opacity (i.e., fibrosis). Follow-up chest radiographs were also evaluated for pleural thickening, pleural effusion, pneumothorax and lymphadenopathy. Patients were categorized into two groups: group 1 (no evidence of lung fibrosis) and group 2 (chest radiographic evidence of lung fibrosis) for comparative analysis. Patient demographics, length of ventilations days, number of intensive care unit (ICU) admission days, chest radiographic score, chest radiographic deterioration pattern (Types 1-4) and peak lactate dehydrogenase level were compared between the two groups using the student t-test, Mann-Whitney U test and Fisher's exact test. Results: Follow-up chest radiographs were normal in 23 out of 36 (64%) patients. Among the patients with abnormal chest radiographs (13/36, 36%), the following were found: lung fibrosis in 12 (33%) patients GGO in 2 (5.5%) patients, and pleural thickening in 2 (5.5%) patients. Patients with lung fibrosis had significantly greater number of ICU admission days (19 ± 8.7 days; P value = 0.001), older age (50.6 ± 12.6 years; P value = 0.02), higher chest radiographic scores [10 (0-15.3); P value = 0.04] and higher peak lactate dehydrogenase levels (315-370 U/L; P value = 0.001) when compared to patients without lung fibrosis. Conclusion: Lung fibrosis may develop in a substantial number of patients who have recovered from Middle East respiratory syndrome coronavirus (MERS-CoV). Significantly greater number of ICU admission days, older age, higher chest radiographic scores, chest radiographic deterioration patterns and peak lactate dehydrogenase levels were noted in the patients with lung fibrosis on follow-up chest radiographs after recovery from MERS-CoV. [ABSTRACT FROM AUTHOR]

المؤلفون: Prineethi, Sheena¹ (AUTHOR), Irodi, Aparna¹ (AUTHOR), Eapen, Anu¹ (AUTHOR), Milton, Sharon² (AUTHOR), Joel, Anjana^3,4 (AUTHOR) anjanajoel@gmail.com

المصدر: Indian Journal of Radiology & Imaging. Sep2022, Vol. 32 Issue 3, p301-307. 7p.

مصطلحات موضوعية: *ALPHA fetoproteins, *CANCER chemotherapy, *METASTASIS, *TERATOMA, *TUMOR classification, *RISK assessment, *TREATMENT effectiveness, *LACTATE dehydrogenase, *TUMOR markers, *DECISION making in clinical medicine, *COMPUTED tomography, *CHORIONIC gonadotropins, *EARLY diagnosis

مستخلص: Context Growing teratoma syndrome (GTS) is a rare entity seen following chemotherapy for metastatic nonseminomatous germ cell tumors, characterized by increase in size of the metastatic deposits, with normal serum tumor markers. Aims In this article, we aim to describe the various clinicoradiological presentations of GTS treated at our center. Design All patients who satisfied the GTS criteria from 2001 to 2019 were included. Characteristic imaging appearances along with sites of primary lesion and metastatic disease, stage and risk stratification at diagnosis, details of chemotherapy, details of surgical treatment and histopathology, levels of tumor markers, serum β-human chorionic gonadotropin, lactate dehydrogenase, and alpha fetoprotein levels at baseline and at the end of all chemotherapy were analyzed. Results The significant radiological findings observed were an increase in the fat and cystic components and appearance of coarse calcifications within the lesions. Majority of the cases were male patients (87.5%) with testicular primaries and GTS transformation in nodal metastases being the most common occurrence (75%). All eight cases (100%) showed an increase in size and cystic component, whereas four out of eight cases (50%) had presence of internal septations and internal calcification. Conclusion Early recognition of this entity and clinical decision making through serial radiological imaging are of utmost importance as these growing deposits are resistant to chemotherapy and radiotherapy, with complete surgical excision being the only curative and definitive treatment option. [ABSTRACT FROM AUTHOR]

المؤلفون: Shanthala, S.^1,2 (AUTHOR) drshanthalas@gmail.com, Kavitha, B. L.² (AUTHOR), Kumari, Prasanna² (AUTHOR), Vijay, C.R.³ (AUTHOR), Lokanatha, D.⁴ (AUTHOR), Appaji, L.⁵ (AUTHOR), Babu, Govind⁴ (AUTHOR), Premalata, C. S.⁶ (AUTHOR), Ramachandra, C.⁷ (AUTHOR)

المصدر: Indian Journal of Medical & Paediatric Oncology. Aug2022, Vol. 43 Issue 4, p349-354. 6p.

مصطلحات موضوعية: *LYMPHOBLASTIC leukemia, *ACUTE leukemia, *B cells, *BONE marrow, *LACTATE dehydrogenase

مستخلص: Introduction Cytogenetic abnormalities are integral to the risk stratification of acute lymphoblastic leukemia (ALL). Objectives The present study aimed to highlight a rare, yet nonrandom cytogenetic abnormality notably dicentric (9;12), which was observed in ALL patients who presented to our institute. The study analyzed the frequency, clinicohematological features, and treatment response of these patients. Materials and Methods A single-group observational study was conducted from April 2014 to April 2020. Cytogenetic analysis was done on bone marrow aspirate samples of the patients referred to the cytogenetics laboratory with clinical diagnosis of acute leukemia. Cytogenetic, clinical, and hematological data were collected from respective departmental records, case files, and patients. Results Dic(9;12) was identified in 1.2% of ALL (19 out of 1,544 patients). They showed striking preponderance in teen and young adult males with characteristic precursor B cell immunophenotype. Majority of these patients displayed favorable risk profiles such as low total count, mild lymphadenopathy and splenomegaly, mild-to-moderate elevation of lactate dehydrogenase, and good response to first induction chemotherapy. Rare coexistence of dic(9;12) with well-established cytogenetic markers such as t(9;22) and t(1;19) was observed. Conclusion Dic(9;12) is one of the most specific cytogenetic markers of precursor B cell (pre-B) ALL. It defines a subgroup with favorable clinical and biological profile. We suggest inclusion of dic(9;12) in cytogenetic risk stratification of precursor B cell ALL. Long-term follow-up studies are recommended to establish the prognostic significance of this cytogenetic subgroup, which may benefit from less intensive chemotherapy. [ABSTRACT FROM AUTHOR]

المؤلفون: Kalekar, Tushar M.¹ (AUTHOR), Jaipuria, Radhika K.¹ (AUTHOR), Navani, Rahul Srichand¹ (AUTHOR) drrsnradio@gmail.com

المصدر: Indian Journal of Radiology & Imaging. Jun2022, Vol. 32 Issue 2, p256-259. 4p.

مصطلحات موضوعية: *SHOULDER pain, *RHABDOMYOLYSIS, *COVID-19 vaccines, *INFLAMMATION, *SERUM, *MAGNETIC resonance imaging, *CREATINE kinase, *LEG, *DOPPLER ultrasonography, *LACTATE dehydrogenase, *EDEMA

مستخلص: In the era of this pandemic, without any proper and efficacious availability of antiviral agents against the novel coronavirus disease 2019 (COVID-19), vaccines have come as a hope for humankind. Although adverse reactions are common after getting the COVID-19 vaccine, serious or life-threatening side effects are very uncommon in these new emergency-approved vaccines. In this case report, we describe an unusual case of adverse reaction in a patient who received the COVID-19 vaccination. The patient who received the COVID-19 vaccination presented with progressive right lower limb pain and swelling, which further progressed to bilateral shoulder pain and swelling. Ultrasonography, Doppler, and magnetic resonance imaging of right lower limb were done for the patient. [ABSTRACT FROM AUTHOR]

المؤلفون: Rajalingam, Bavaharan¹ (AUTHOR), Narayanan, Ethirajan² (AUTHOR), Nirmalan, Praveen³ (AUTHOR), Muthukrishnan, Kamalanthan⁴ (AUTHOR), Sundaram, Vivek⁵ (AUTHOR), Kumaravelu, Saravanan⁶ (AUTHOR), Gopalan, Mukundhan⁷ (AUTHOR), Jeyapal, Senthil⁸ (AUTHOR), Rajalingam, Baskaran⁹ (AUTHOR), Khanna, Vijay¹⁰ (AUTHOR), Dhoss, Praveen¹¹ (AUTHOR), Gopinath¹² (AUTHOR)

المصدر: Indian Journal of Radiology & Imaging. 2021Supplement, Vol. 31, p110-118. 9p.

مصطلحات موضوعية: *LUNG radiography, *STEROID drugs, *ANTICOAGULANTS, *BIOMARKERS, *COMPARATIVE studies, *COMPUTED tomography, *CONVALESCENCE, *STATISTICAL correlation, *FERRITIN, *LACTATE dehydrogenase, *OXYGEN, *CROSS-sectional method, *DISEASE progression, *EARLY medical intervention, *FIBRIN fibrinogen degradation products, *EARLY diagnosis, *COVID-19

مصطلحات جغرافية: INDIA

مستخلص: Aim: To describe the distribution of lung patterns determined by High Resolution Computed Tomography (HRCT) in COVID patients with mild and moderate lung involvement and outcomes after early identification and management with steroids and anticoagulants. Material and Methods: A cross sectional study of COVID-19 patients with mild and moderate lung involvement presenting at 5 healthcare centres in Trichy district of South TamilNadu in India. Patients underwent HRCT to assess patterns and severity of lung involvement, Inflammatory markers (LDH/Ferritin) and D-Dimer assay and clinical correlation with signs and symptoms. Patients were assessed for oxygen, steroid and anticoagulant therapy, clinical recovery or progression on follow up and details on mortality were collected. The RSNA, Fleischer Society guidelines and CORADS score was used for radiological reporting. New potential classification of patterns of percentage of lung parenchyma involvement in Covid patients is being suggested. Results: The study included 7,340 patients with suspected COVID and 3,963 (53.9%) patients had lung involvement based on HRCT. RT PCR was positive in 74.1% of the CT Positive cases. Crazy Pavement pattern was predominant (n = 2022, 51.0%) and Ground Glass Opacity (GGO) was found in 1,941 (49.0%) patients in the study. Severe lung involvement was more common in the Crazy Pavement pattern. Patients with GGO in moderate lung involvement were significantly more likely to recover faster compared to Crazy Pavement pattern (P value <0.001). Conclusion: HRCT chest and assessment of lung patterns can help triage patients to home quarantine and hospital admission. Early initiation of steroids and anticoagulants based on lung patterns can prevent progression to more severe stages and aid early recovery. HRCT can play a major role to triage and guide management especially as RT PCR testing and results are delayed for the benefit of patients and in a social cause to decrease the spread of the virus [ABSTRACT FROM AUTHOR]

المؤلفون: Meena, Jagdish Prasad¹, Gupta, Aditya Kumar¹ adivick@gmail.com, Parihar, Mansingh¹, Seth, Rachna¹

المصدر: Indian Journal of Medical & Paediatric Oncology. Jan-Mar2019, Vol. 40 Issue 1, p41-47. 7p.

مصطلحات موضوعية: *LYMPHOMAS, *BURKITT'S lymphoma, *TERTIARY care, *HOSPITAL care, *LACTATE dehydrogenase

مصطلحات جغرافية: INDIA

الشركة/الكيان: NATIONAL Hockey League 138084298

مستخلص: Background: Non.Hodgkin's lymphoma (NHL) is an aggressive malignancy. Its outcome has improved over the past decades. Although it accounts for 8%.10% of all childhood cancers, very less information about its clinical presentation and outcomes is available from India. Our objective was to study the clinical presentation and outcomes in children (<15 years) with NHL at our center. Methodology: We retrospectively analyzed 26 children diagnosed with NHL at our center from August 2008 to June 2014 and followed them up to May 2017. Results: The median age at the time of diagnosis was 7.7 years (2.5.13 years). Abdominal distension and an abdominal lump were the most common presenting features occurring in 75%, followed by fever (73.8%) and weight loss (46.2%). Most patients had advanced.stage (Stage III/IV, 92.3%) disease at presentation. The primary presentation was extranodal in 57.7%, nodal in 26.9%, and combined in 15.4%. Burkitt's lymphoma (BL) was the most common subtype (46.2%), followed by T.lymphoblastic lymphoma, diffuse large B.cell lymphoma, and anaplastic large.cell lymphoma. Three patients did not take treatment. The median follow.up of patients was 48 months (36.99 months). Nineteen patients achieved remission and four had progressive disease. Significantly better event.free survival (EFS) was found with younger age and lower stage of presentation. The EFS did not significantly differ with sex, group of disease, lactate dehydrogenase levels, and presenting features. Conclusions: Our cohort of patients with NHL showed characteristics similar to those reported from other developing countries. NHL occurred at a younger age, with a higher incidence of BL. The outcome for patients aged >10 years was poor. The outcome of NHL was comparable to that of other centers in the world. [ABSTRACT FROM AUTHOR]