التفاصيل البيبلوغرافية
| العنوان: |
Protective effect of remote liver ischemic postconditioning on pulmonary ischemia and reperfusion injury in diabetic and non-diabetic rats. |
| المؤلفون: |
Huang, Dou1,2 (AUTHOR), Chen, Changwei1,2 (AUTHOR), Zuo, Yunxia1,2 (AUTHOR), Du, Lei1,2 (AUTHOR), Liu, Ting2 (AUTHOR), Abbott, Geoffrey W.3 (AUTHOR), Hu, Zhaoyang2 (AUTHOR) zyhu@hotmail.com |
| المصدر: |
PLoS ONE. 5/26/2022, Vol. 17 Issue 5, p1-17. 17p. |
| مصطلحات موضوعية: |
*LUNGS, *MYOCARDIAL reperfusion, *REPERFUSION injury, *ISCHEMIC postconditioning, *RATS, *APOPTOSIS inhibition, *LIVER |
| مستخلص: |
Pulmonary ischemia and reperfusion (I/R) injury occurs in many clinical conditions and causes severe damage to the lungs. Diabetes mellitus (DM) predisposes to pulmonary I/R injury. We previously found that remote liver ischemia preconditioning protected lungs against pulmonary I/R injury. The aim of the present study was to investigate whether remote liver ischemic postconditioning (RLIPost) attenuates pulmonary damage induced by I/R injury in non-diabetic or diabetic rats. Male Sprague-Dawley rats were assigned into non-diabetic and diabetic groups. All rats except for the sham were exposed to 45 min of left hilum occlusion followed by 2 h of reperfusion. RLIPost was conducted at the onset of pulmonary reperfusion by four cycles of 5 min of liver ischemia and reperfusion. Lung injury was assessed by the wet/dry weight ratio, pulmonary oxygenation, histopathological changes, apoptosis and the expression of inflammatory cytokines. Reperfusion-associated protein phosphorylation states were determined. RLIPost offered strong pulmonary-protection in both non-diabetic and diabetic rats, as reflected in reduced water content and pulmonary structural damage, recovery of lung function, inhibition of apoptosis and inflammation after ischemia-reperfusion. RLIPost induced the activation of pulmonary STAT-3, a key component in the SAFE pathway, but not activation of the proteins in the RISK pathway, in non-diabetic rats. In contrast, RLIPost-induced pulmonary protection in diabetic lungs was independent of SAFE or RISK pathway activation. These results demonstrate that RLIPost exerts pulmonary protection against I/R-induced lung injury in non-diabetic and diabetic rats. The underlying mechanism for protection may be different in non-diabetic (STAT-3 dependent) versus diabetic (STAT-3 independent) rats. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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