التفاصيل البيبلوغرافية
| العنوان: |
Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases. |
| المؤلفون: |
Duval, Florent1 (AUTHOR), Elva Cruz-Vega, Delia1 (AUTHOR) cruzvegade@gmail.com, González-Gamboa, Ivonne2 (AUTHOR), Teresa González-Garza, María1 (AUTHOR), Ponz, Fernando2 (AUTHOR), Sánchez, Flora2 (AUTHOR), Alarcón-Galván, Gabriela3 (AUTHOR), Moreno-Cuevas, Jorge E.1 (AUTHOR) |
| المصدر: |
Disease Markers. 4/24/2016, p1-7. 7p. 1 Chart, 2 Graphs. |
| مستخلص: |
There is a need for new noninvasive biomarkers (NIBMs) able to assess cholestasis and fibrosis in chronic cholestatic liver diseases (CCLDs). Tumorigenesis can arise from CCLDs. Therefore, autoantibodies to tumor-associated antigens (TAA) may be early produced in response to abnormal self-antigen expression caused by cholestatic injury. Vascular endothelial growth factor receptor- 3 (VEGFR-3) has TAA potential since it is involved in cholangiocytes and lymphatic vessels proliferations during CCLDs. This study aims to detect autoantibodies directed at VEGFR-3 during bile duct ligation- (BDL-) induced cholestatic injury in rat sera and investigate whether they could be associated with traditional markers of liver damage, cholestasis, and fibrosis. An ELISA was performed to detect anti-VEGFR-3 autoantibodies in sera of rats with different degree of liver injury and results were correlated with aminotransferases, total bilirubin, and the relative fibrotic area. Mean absorbances of anti-VEGFR-3 autoantibodies were significantly increased from week one to week five after BDL. The highest correlation was observed with total bilirubin (𝑅² = 0.8450, 𝑃 = 3.04𝑒 − 12). In conclusion, anti-VEGFR-3 autoantibodies are early produced during BDL-induced cholestatic injury, and they are closely related to cholestasis, suggesting the potential of anti-VEGFR-3 autoantibodies as NIBMs of cholestasis in CCLDs and justifying the need for further investigations in patients with CCLD. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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