التفاصيل البيبلوغرافية
| العنوان: |
Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants. |
| المؤلفون: |
Soriano-Raya, Juan José1, Miralbell, Júlia1, López-Cancio, Elena2, Bargalló, Núria3,4, Arenillas, Juan Francisco5, Barrios, Maite6, Cáceres, Cynthia2, Toran, Pere7,8, Alzamora, Maite7,9, Dávalos, Antoni2, Mataró, Maria1,10 |
| المصدر: |
Journal of the International Neuropsychological Society. Sep2012, Vol. 18 Issue 5, p874-885. 12p. |
| مصطلحات موضوعية: |
*PERIAQUEDUCTAL gray matter, *COGNITIVE ability, *DEMENTIA, *MAGNETIC resonance imaging of the brain, *COGNITION disorders, *EXECUTIVE function, *PSYCHOMOTOR disorders |
| مستخلص: |
The association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12) [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
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