المؤلفون: Acquitter, Marie¹, Plantin, Patrice¹, Kupfer, Ingrid¹, Auvinet, Henri², Marhadour, Thierry²

المصدر: Annals of Internal Medicine. 7/7/2015, Vol. 163 Issue 1, p70-71. 2p. 1 Color Photograph.

مصطلحات موضوعية: *ANTIARTHRITIC agents, *PSORIATIC arthritis, *DOPPLER ultrasonography, *THROMBOSIS, *PATIENTS, *THERAPEUTICS, LEG ulcers

مستخلص: The article presents a case study of a 46-year-woman presented with a painful, deep ulcer in the left leg. Topics include medical history of diagnosed with plaque psoriasis at age 7 years and destructive axial and peripheral polyarthritis since age 18 years, sacroiliitis typical of psoriatic arthritis diagnosed in computed tomography and no signs of venous or arterial thrombosis or arteriopathy revealed in Doppler ultrasonography, and treatment by anakinra therapy for Pyoderma gangrenosum.

المؤلفون: Pourchot, Diane¹, Bodemer, Christine², Phan, Alice³, Bursztejn, Anne ‐ Claire⁴, Hadj ‐ Rabia, Smaïl², Boralevi, Franck⁵, Miquel, Juliette⁶, Hubiche, Thomas⁷, Puzenat, Eve⁸, Souillet, Anne ‐ Laure³, Kupfer, Ingrid⁹, Piram, Maryam¹⁰, Beauchet, Alain¹¹, Mahé, Emmanuel¹ emmanuel.mahe@ch-argenteuil.fr

المصدر: Pediatric Dermatology. Jan/Feb2017, Vol. 34 Issue 1, p58-63. 6p.

مصطلحات موضوعية: *DISEASE risk factors, *PSORIASIS, *PEDIATRIC diagnosis, *DIAGNOSIS, *PATIENTS

مستخلص: Background/Objectives Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. Methods We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included. Clinical features of the nails were collected. Association with clinical aspects of the disease and comorbidities were evaluated. Results Of 313 children with psoriasis (mean age 9.1 ± 4.2 yrs; 149 boys, 164 girls), 31.1% had familial psoriasis and 30% had severe psoriasis. The mean age at onset was 6.1 ± 3.7 years. Nails were involved in 32.3% of children. The main clinical aspects were pitting (69.1%) for fingernails and onycholysis (40.0%) and pachyonychia (27.5%) for toenails. All of the fingers were involved at similar frequencies, whereas the big toe was involved twice as often as the others (p < 0.005). Nail involvement was associated with male sex (p < 0.001), palmoplantar psoriatic (p < 0.001), severity of disease (p = 0.003), and psoriatic arthritis (p = 0.03). Conclusion The prevalence of nail involvement was 32.3% in children with psoriasis. Clinical aspects in children are reported, as well as clinical associations. As in adults, nail psoriasis is closely associated with psoriatic arthritis. [ABSTRACT FROM AUTHOR]

المؤلفون: Lepretre, Stéphane¹ slepretre@rouen.fnclcc.fr, Jardin, Fabrice¹, Buchonnet, Gérard², Lenain, Pascal¹, Stamatoullas, Aspasia¹, Kupfer, Ingrid³, Courville, Philippe³, Callat, Marie-Paule², Contentin, Nathalie¹, Bastard, Christian^4,5, Tilly, Hervé^1,5

المصدر: Cancer Genetics & Cytogenetics. Mar2002, Vol. 133 Issue 2, p164. 4p.

مصطلحات موضوعية: *HEMATOPOIETIC system, *EOSINOPHIL disorders, *CYTOGENETICS, *GENETICS, *DISEASES

مستخلص: Chromosomal aberrations have been reported in most malignant hematopoietic disorders such as acute or chronic myeloid leukemia, acute lymphoid leukemia, and myelodysplastic syndromes. Eosinophilic leukemia is a rare hematologic malignancy difficult to distinguish from other forms of idiopathic hypereosinophilic syndrome, so that the diagnosis is often made by exclusion, unless cytogenetic abnormalities can be demonstrated in bone marrow cells. We describe a patient with eosinophilic leukemia whose cytogenetic study shows a t(2;5)(p23;q31). Initial data could suggest a clonal eosinophilia, with an hepatosplenomegaly, severe pancytopenia, and a high level of blood and medullar eosinophilia. [Copyright &y& Elsevier]