التفاصيل البيبلوغرافية
| العنوان: |
右美托咪定复合舒芬太尼自控镇痛对剖宫产产妇应激反应和 炎症介质的影响. |
| العنوان البديل: |
Effects of Dexmedetomidine Combined with Sufentanil Self Controlled Analgesia on Stress Response and Inflammatory Mediators in Cesarean Section Women. |
| المؤلفون: |
潘文星1 mytxlsfw@126.com, 张绍义1 zhangzhaoyi6579@126.com, 余云明1, 余承易1, 高德胜1, 刘 超1 |
| المصدر: |
Progress in Modern Biomedicine. 7/15/2020, Vol. 20 Issue 13, p2560-2563. 4p. |
| مصطلحات موضوعية: |
*SELF-control, *INFLAMMATORY mediators, *INFLAMMATION, *CESAREAN section, *C-reactive protein, *URINARY stress incontinence, *OBSTETRICAL analgesia, *LABOR pain (Obstetrics) |
| الملخص (بالإنجليزية): |
Objective: To investigate the effect of dexmedetomidine combined with sufentanil self controlled analgesia on stress response and inflammatory mediators in cesarean section women. Methods: From April 2017 to April 2019, 105 cases of parturient undergoing cesarean section in our hospital were selected. According to the method of random number table, the patients were divided into study group (n=53) and control group (n=52). The control group was given sufentanil self controlled analgesia, and the study group was dexmedetomidine combined with sufentanil self controlled analgesia on the basis of the control group. The visual pain simulation score (VAS), Ramsay sedation score, stress response and inflammatory mediators indexes were compared between the two groups. The use of automatic analgesia pump and the occurrence of adverse reactions during analgesia were recorded in the two groups within 48 h after the operation. Results: The VAS scores of the two groups were decreased at 2 h, 12 h, 24 h and 48 h after operation, and that of the study group at 2 h, 12 h, 24 h and 48 h after operation were lower than that of the control group (P<0.05). The Ramsay sedation score of the study group at 2 h, 12 h, 24 h and 48 h after operation were higher than that of the control group (P<0.05). The levels of serum cortisol (COR), tumor necrosis factor-α (TNF-α), noradrenaline (NE), C-reactive protein (CRP), endothelin -1 (ET-1) and interleukin -10 (IL-10) in the two groups decreased at 48 hours after operation, and those of the study group were lower than those of the control group(P<0.05). The dosage of sufentanil and the times of compression of analgesia pump of the study group were less than those of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dexmedetomidine combined with sufentanil self controlled analgesia can effectively reduce the body stress response and inflammatory mediators, as well as the dosage of sufentanil and the number of times of compression of analgesia pump. It has good safety, and it has a high clinical application value. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的：探讨右美托咪定复合舒芬太尼自控镇痛对剖宫产产妇应激反应和炎症介质的影响。方法：选取 2017 年 4 月 ~2019 年 4 月期间在我院行剖宫产术的产妇 105 例，根据乱数表法将患者分为研究组（n=53）和对照组（n=52），其中对照组采用舒芬太尼自 控镇痛方案，研究组采用右美托咪定复合舒芬太尼自控镇痛方案，比较两组视觉疼痛模拟评分（VAS）、Ramsay 镇静评分、应激反 应和炎症介质指标，记录两组术后 48 h 内自控镇痛泵使用情况、镇痛期间不良反应发生情况。结果：两组术后 2 h、12 h、24 h、48 h VAS 评分均呈下降趋势，且研究组术后 2 h、12 h、24 h、48 h VAS 评分低于对照组（P<0.05），研究组术后 2 h、12 h、24 h、48 h Ramsay 镇静评分高于对照组（P<0.05）。两组术后 48h 血清皮质醇（Cor）、肿瘤坏死因子 -琢（TNF-琢）、甲肾上腺素（NE）、C 反应蛋白 （CRP）、内皮素 -1（ET-1）、白介素 -10（IL-10）水平均升高，但研究组低于对照组（P<0.05）。研究组术后 48 h 内舒芬太尼用量、镇痛 泵按压次数均少于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：采用右美托咪定复合舒芬太尼自控镇痛方 案可有效减轻剖宫产产妇应激反应并降低其炎症介质水平，同时还可减少舒芬太尼用量和镇痛泵按压次数，用药安全性较好，临 床应用价值较高。 [ABSTRACT FROM AUTHOR] |
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