التفاصيل البيبلوغرافية
| العنوان: |
Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities. |
| المؤلفون: |
Calderón-Gonzalez, Ricardo1 ricardocalderongonzalez@hotmail.com, Terán-Navarro, Héctor1 hteran35@hotmail.com, Frande-Cabanes, Elisabet1 desli87@hotmail.com, Ferrández-Fernández, Eva1 ferrandez.eva@gmail.com, Freire, Javier2 javifreiresalinas@gmail.com, Penadés, Soledad3,4 spenades@cicbiomagune.es, Marradi, Marco3,4,5 marcomarradi76@gmail.com, Gomez-Román, Javier2 apagrj@humv.es, Yañez-Díaz, Sonsoles5 syanez@humv.es, Álvarez-Domínguez, Carmen1 calvarez@humv.es, García, Isabel3,4 igarcia.ciber-bbn@cicbiomagune.es |
| المصدر: |
Nanomaterials (2079-4991). Aug2016, Vol. 6 Issue 8, p151. 11p. |
| مصطلحات موضوعية: |
*LISTERIA monocytogenes, *LISTERIOSIS vaccines, *PREGNANT women |
| مستخلص: |
Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91-99 (LLO91-99) or glyceraldehyde-3-phosphate dehydrogenase 1-22 peptide (GAPDH1-22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes. Therefore, these nanoparticle vaccines are effective measures to offer pregnant mothers at high risk of listeriosis interesting therapies that cross the placenta. [ABSTRACT FROM AUTHOR] |
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