التفاصيل البيبلوغرافية
| العنوان: |
Effect of estradiol on oocyte development |
| المؤلفون: |
Bianco, Katherine1 biancok@obgyn.ucsf.edu, Mahutte, Neal G.2, Arici, Aydin2, Sakkas, Denny2, Taylor, Hugh S.2 |
| المصدر: |
International Journal of Gynecology & Obstetrics. Mar2009, Vol. 104 Issue 3, p230-232. 3p. |
| مصطلحات موضوعية: |
*ESTRADIOL, *OVUM, *REPRODUCTION, *FERTILIZATION in vitro, *ENDOMETRIUM physiology, *OVUM physiology, *CELL physiology, *EMBRYO transfer, *FOLLICLE-stimulating hormone, *LONGITUDINAL method, *EVALUATION of medical care, *PREGNANCY, *EMBRYOS, *OVUM donation, *RETROSPECTIVE studies |
| مستخلص: |
Abstract: Objective: To determine whether elevated serum estradiol (E2) concentrations in oocyte donors affect assisted reproduction outcome. Method: In a retrospective cohort study of 58 consecutive oocyte donation cycles, donors were stratified into 2 groups according to E2 concentration, group 1 (n=32; E2 ≤2000 pg/mL [range 456–2000 pg/mL]) and group 2 (n=27; E2 >2000 pg/mL [range, 2062–6957 pg/mL]). Data were analyzed using the t test and χ2 test. Results: Donors in group 1 produced significantly less oocytes than donors in group 2 (19.3±1.7 vs 12.0±1.4; P <0.001), and recipients of oocytes from group 1 had significantly fewer numbers of embryos available for transfer (10.4±1.1 vs 6.4±0.8; P =0.003). However, the mean number (3.3) of embryos transferred and the pregnancy rate were the same in both groups. Conclusion: Elevated estradiol concentration in oocyte donors did not affect pregnancy outcome, suggesting that estradiol levels in donors do not affect oocyte development. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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