التفاصيل البيبلوغرافية
| العنوان: |
Event-related potentials elicited by the Deutsch "high-low" word illusion in the patients with first-episode schizophrenia with auditory hallucinations. |
| المؤلفون: |
You Xu1, Hao Chai1, Bingren Zhang1, Qianqian Gao1, Hongying Fan1, Leilei Zheng2, Hongjing Mao3, Yonghua Zhang3, Wei Wang1,3 drwangwei@zju.edu.cn |
| المصدر: |
BMC Psychiatry. 2/18/2016, Vol. 16, p1-10. 10p. 1 Color Photograph, 2 Diagrams, 2 Charts. |
| مصطلحات موضوعية: |
*EVOKED potentials (Electrophysiology), *AUDITORY hallucinations, *SCHIZOPHRENIA, *SYMPTOMS, *CINGULATE cortex, *BRAIN imaging |
| مستخلص: |
Background: The exact cerebral structural and functional mechanisms under the auditory verbal hallucinations (AVHs) in schizophrenia are still unclear. The Deutsch "high-low" word illusion might trigger attentional responses mimicking those under AVHs. Methods: We therefore have invited 16 patients with first-episode, paranoid schizophrenia, and 16 age- and gender-matched healthy volunteers to undergo the "oddball" event-related potentials elicited by the illusion. The clinical characteristics of patients were measured with the positive and negative symptom scale. Results: Besides the longer reaction time to the illusion, the standard P2 latency was shortened, the N2 latency was prolonged, and both N1 and P3 amplitudes were reduced in patients. The P3 source analyses showed the activated bilateral temporal lobes, parietal lobe and cingulate cortex in both groups, left inferior temporal gyrus in controls, and left postcentral gyrus in schizophrenia. Moreover, the N1 amplitude was positively correlated with the paranoid score in patients. Conclusions: Our results were in line with previous neurophysiological and neuroimaging reports of hallucination or auditory processing in schizophrenia, and illustrated a whole process of cerebral information processing from N1 to P3, indicating this illusion had triggered a dynamic cerebral response similar to that of the AVHs had engaged. [ABSTRACT FROM AUTHOR] |
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