Data from: Intestinal Ralstonia pickettii augments glucose intolerance in obesity
| العنوان: | Data from: Intestinal Ralstonia pickettii augments glucose intolerance in obesity |
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| المؤلفون: | Udayappan, Shanthadevi, Kovatcheva-Datchary, Petia, Bakker, Guido, Havik, Stefan, Herrema, Hilde, Cani, Patrice, Bouter, Kristien, Belzer, Clara, Witjes, Julia J., Vrieze, Anne, de Sonnaville, Eleonore Susanne Victoria, Chaplin, Alice, van Raalte, Daniel, Aalvink, Steven, Dallinga-Thie, Geesje, Heilig, Hans, Bergstrom, Goran, van der Meij, Suzan, Van Wagensveld, Bart, Hoekstra, Joost, Holleman, Frits, Stroes, Erik, Groen, Albert, Backhed, Fredrik, de Vos, Willem, Nieuwdorp, Max, Udayappan, Shanthadevi D., Bakker, Guido J., Havik, Stefan R., Bouter, Kristien E., Dallinga-Thie, Geesje M., Stroes, Erik S. G., Groen, Albert K., Heilig, Hans G. H. J., de Vos, Willem M., de Sonnaville, Noor, Hoekstra, Joost B. L., van Raalte, Daniel H. |
| سنة النشر: | 2018 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | glucose intolerance, Ralstonia pickettii, Obesity |
| الوصف: | An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent. Interestingly, fecal abundance of Ralstonia pickettii was increased in obese subjects with pre-diabetes and T2DM. To assess if R. pickettii was causally involved in development of obesity and T2DM, we performed a proof-of-concept study in diet-induced obese (DIO) mice. Compared to vehicle-treated control mice, R. pickettii-treated DIO mice had reduced glucose tolerance. In addition, circulating levels of endotoxin were increased in R. pickettii-treated mice. In conclusion, this study suggests that intestinal Ralstonia is increased in obese human subjects with T2DM and reciprocally worsens glucose tolerance in DIO mice. ; DryadPlosOneUdayappanGraphPad Prism file containing data belonging to Udayappan et al, Intestinal Ralstonia pickettii augments glucose intolerance in obesity, MS #: PONE-D-17-01669 DOI:10.1371/journal.pone.0181693 |
| نوع الوثيقة: | dataset |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/communities/dryadTest; https://zenodo.org/record/5006883Test; https://doi.org/10.5061/dryad.q5s51Test; oai:zenodo.org:5006883 |
| DOI: | 10.5061/dryad.q5s51 |
| الإتاحة: | https://doi.org/10.5061/dryad.q5s51Test https://doi.org/10.1371/journal.pone.0181693Test https://zenodo.org/record/5006883Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/publicdomain/zero/1.0/legalcodeTest |
| رقم الانضمام: | edsbas.5824FA64 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5061/dryad.q5s51 |
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