التفاصيل البيبلوغرافية
| العنوان: |
Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in mycosis fungoides and Sezary syndrome |
| المؤلفون: |
Jones, Christine, Degasperi, Andrea, Grandi, Vieri, Mitchell, Tracey, Nik-Zainal, Serena |
| بيانات النشر: |
Zenodo |
| سنة النشر: |
2019 |
| المجموعة: |
Zenodo |
| مصطلحات موضوعية: |
Cancer genomics, cutaneous T-cell lymphoma, T-cell non-Hodgkin's lymphoma, Angioimmunoblastic T-cell lymphoma, Hepatosplenic T-cell lymphoma, Enteropathy associated T-cell lymphoma, Adult T-cell lymphoma/leukemia, Mycosis Fungoides, Sézary Syndrome, NK/T-cell lymphoma |
| الوصف: |
T-cell non-Hodgkin's lymphomas (NHL) develop following transformation of tissue resident T-cells. We performed a meta-analysis of mutational catalogues derived from whole exome sequencing data from 403 patients with eight subtypes of T-cell NHL to identify mutational signatures and recurrent gene mutations associated with specific causal peaks within these signatures. Signature 1, indicative of age-related deamination, was prevalent across all T-cell NHL subtypes, reflecting the derivation of these malignancies from memory T-cell subsets. Adult T-cell leukemia-lymphoma (ATLL) was specifically associated with signature 17, which was found to strongly correlate with the IRF4 K59R mutation that is exclusive to ATLL. Signature 7, implicating UV exposure as a potential initiating factor was uniquely identified in cutaneous T-cell lymphoma, contributing 52% of the mutational burden in mycosis fungoides and 23% in Sezary syndrome. Importantly this UV signature was observed in CD4+ T-cells isolated from blood suggesting extensive re-circulation of these T-cells through both skin and blood and strongly implicating a role for UV in the pathogenesis of cutaneous T-cell lymphoma. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
unknown |
| العلاقة: |
https://doi.org/10.5061/dryad.97c7v3kTest; https://zenodo.org/communities/dryadTest; https://doi.org/10.5061/dryad.8cz8w9gkmTest; oai:zenodo.org:4984202 |
| DOI: |
10.5061/dryad.8cz8w9gkm |
| الإتاحة: |
https://doi.org/10.5061/dryad.8cz8w9gkmTest
https://doi.org/10.5061/dryad.97c7v3kTest |
| حقوق: |
info:eu-repo/semantics/openAccess ; Creative Commons Zero v1.0 Universal ; https://creativecommons.org/publicdomain/zero/1.0/legalcodeTest |
| رقم الانضمام: |
edsbas.F16C1C1A |
| قاعدة البيانات: |
BASE |
