دورية أكاديمية
Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study
| العنوان: | Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study |
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| المؤلفون: | Bartlett, David B., Willis, Leslie H., Slentz, Cris A., Hoselton, Andrew, Kelly, Leslie, Huebner, Janet L., Kraus, Virginia B., Moss, Jennifer, Muehlbauer, Michael J., Spielmann, Guillaume, Kraus, William E., Lord, Janet M., Huffman, Kim M. |
| المصدر: | Arthritis Research & Therapy 20(1) 127 |
| سنة النشر: | 2018 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Rheumatoid arthritis, Disease activity, Innate immunity, Inflammation, High-intensity interval exercise |
| الوصف: | Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infection. Exercise training can improve the health of patients with RA and potentially improve immune function; however, information on the effects of high-intensity interval training (HIIT) in RA is limited. We sought to determine whether 10 weeks of a walking-based HIIT program would be associated with health improvements as measured by disease activity and aerobic fitness. Further, we assessed whether HIIT was associated with improved immune function, specifically antimicrobial/bacterial functions of neutrophils and monocytes.Methods: Twelve physically inactive adults aged 64 ± 7 years with either seropositive or radiographically proven (bone erosions) RA completed 10 weeks of high-intensity interval walking. Training consisted of 3 × 30-minute sessions/week of ten ≥ 60-second intervals of high intensity (80–90% VO2reserve) separated by similar bouts of lower-intensity intervals (50–60% VO2reserve). Pre- and postintervention assessments included aerobic and physical function; disease activity as measured by Disease Activity score in 28 joints (DAS28), self-perceived health, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR); plasma interleukin (IL)-1β, IL-6, chemokine (C-X-C motif) ligand (CXCL)-8, IL-10, and tumor necrosis factor (TNF)-α concentrations; and neutrophil and monocyte phenotypes and functions.Results: Despite minimal body composition change, cardiorespiratory fitness increased by 9% (change in both relative and absolute aerobic capacity; p < 0.001), and resting blood pressure and heart rate were both reduced (both p < 0.05). Postintervention disease activity was reduced by 38% (DAS28; p = 0.001) with significant reductions in ESR and swollen joints as well as improved self-perceived health. Neutrophil migration toward CXCL-8 (p ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | info:eu-repo/grantAgreement/EC/FP7/629981/; https://zenodo.org/communities/fp7-bmcTest; https://zenodo.org/record/1291667Test; https://doi.org/10.1186/s13075-018-1624-xTest; oai:zenodo.org:1291667 |
| DOI: | 10.1186/s13075-018-1624-x |
| الإتاحة: | https://doi.org/10.1186/s13075-018-1624-xTest https://zenodo.org/record/1291667Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.E214E129 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13075-018-1624-x |
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