Data from: Correlation of neurochemical and imaging markers in migraine PACAP38 and DTI measures
| العنوان: | Data from: Correlation of neurochemical and imaging markers in migraine PACAP38 and DTI measures |
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| المؤلفون: | Veréb, Dániel, Szabó, Nikoletta, Tuka, Bernadett, Tajti, János, Király, András, Faragó, Péter, Kocsis, Krisztián, Tóth, Eszter, Kincses, Bálint, Bagoly, Teréz, Helyes, Zsuzsanna, Vécsei, László, Kincses, Zsigmond Tamás |
| سنة النشر: | 2019 |
| المجموعة: | Zenodo |
| الوصف: | Objective: This exploratory study examines whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity shows correlation with the microstructural integrity of the white matter in migraine. Methods: Interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity was measured by radioimmunoassay in 26 migraine patients (24 females) who underwent diffusion tensor imaging (DTI) afterwards using a 1.5T MR scanner. Data were analysed using Tract-based Spatial Statistics (TBSS) included in FMRIB's Software Library (FSL). Results: Interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity showed significant correlation with mean diffusivity (p<0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal pituitary adenylate cyclase.activating peptide 38-like immunoreactivity (p<0.0432 and p<0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with pituitary adenylate cyclase-activating peptide 38-like immunoreactivity. With disease duration as a nuisance regressor in the model, pituitary adenylate cyclase-activating peptide 38-like immunoreactivity correlated with axial and mean diffusivity in the left thalamus (p<0.01). Conclusion: We report a link between pituitary adenylate cyclase-activating peptide 38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of pituitary adenylate cyclase-activating peptide 38 in migraine. ; Supplementary materialDifferences in the relationship between PACAP38-LI and diffusion measures in migraine with and without aurasuppl_mat.pdf |
| نوع الوثيقة: | dataset |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/communities/dryadTest; https://zenodo.org/record/4934763Test; https://doi.org/10.5061/dryad.g58811vTest; oai:zenodo.org:4934763 |
| DOI: | 10.5061/dryad.g58811v |
| الإتاحة: | https://doi.org/10.5061/dryad.g58811vTest https://doi.org/10.1212/wnl.0000000000006201Test https://zenodo.org/record/4934763Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/publicdomain/zero/1.0/legalcodeTest |
| رقم الانضمام: | edsbas.A12A78F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5061/dryad.g58811v |
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