Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
| العنوان: | Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine |
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| المؤلفون: | Onderwater, Gerrit L.J., Ligthart, Lannie, Bot, Mariska, Demirkan, Ayse, Fu, Jingyuan, van der Kallen, Carla J.H., Vijfhuizen, Lisanne S., Pool, René, Liu, Jun, Vanmolkot, Floris H.M., Beekman, Marian, Wen, Hoyan, Amin, Najaf, Thesing, Carisha S., Pijpers, Judith A., Kies, Dennis A., Zielman, Ronald, de Boer, Irene, van Greevenbroek, Marleen M.J., Arts, Ilja C.W., Milaneschi, Yuri, Schram, Miranda T., Dagnelie, Pieter C., Franke, Lude, Ikram, M. Arfan, Ferrari, Michel D., Goeman, Jelle J., Slagboom, P. Eline, Wijmenga, Cisca, Stehouwer, Coen D.A., Boomsma, Dorret I., van Duijn, Cornelia M., Penninx, Brenda W., 't Hoen, Peter A.C., Terwindt, Gisela M., van den Maagdenberg, Arn M.J.M. |
| سنة النشر: | 2019 |
| المجموعة: | Zenodo |
| الوصف: | Objective: To identify a plasma metabolomic biomarker signature for migraine. Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analyses. Results: Decreases in the level of apolipoprotein A1 (β −0.10; 95% confidence interval [CI] −0.16, −0.05; adjusted p = 0.029) and free cholesterol to total lipid ratio present in small high-density lipoprotein subspecies (HDL) (β −0.10; 95% CI −0.15, −0.05; adjusted p = 0.029) were associated with migraine status. In addition, only in male participants, a decreased level of omega-3 fatty acids (β −0.24; 95% CI −0.36, −0.12; adjusted p = 0.033) was associated with migraine. Global test analysis further supported that HDL traits (but not other lipoproteins) were associated with migraine status. Conclusions: Metabolic profiling of plasma yielded alterations in HDL metabolism in migraine patients and decreased omega-3 fatty acids only in male migraineurs. ; Methods_e-1_Cohort_backgroundMethods e-1 Cohort background, migraine assessment method, and sampling procedure.Figure_e-1_Influence_of_HeritabilityFigure e-1: Influence of heritability on metabolite estimates and log p-values in ERF and NTR.Figure_e-2_Ratio_stratification_plots_migraine_smokingFigure e-2: ApoA1 and S-HDL-FC ratio stratification plots for migraine and smoking in NESDA and LUMINA.Figure_e-3_Ratio_stratification_plots_migraine_lipid_lowering_medicationFigure e-3: ApoA1 and S-HDL-FC ... |
| نوع الوثيقة: | dataset |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/communities/dryadTest; https://zenodo.org/record/4977081Test; https://doi.org/10.5061/dryad.p698mn7Test; oai:zenodo.org:4977081 |
| DOI: | 10.5061/dryad.p698mn7 |
| الإتاحة: | https://doi.org/10.5061/dryad.p698mn7Test https://doi.org/10.1212/wnl.0000000000007313Test https://zenodo.org/record/4977081Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/publicdomain/zero/1.0/legalcodeTest |
| رقم الانضمام: | edsbas.33DD2BF9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5061/dryad.p698mn7 |
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