التفاصيل البيبلوغرافية
| العنوان: |
Mitochondrial genome sequencing of marine leukemias reveals cancer contagion between clam species in the Seas of Southern Europe |
| المؤلفون: |
Garcia-Souto, Daniel, Diaz-Costas, Seila, Bruzos, Alicia L, Rocha, Sara, Roman-Lewis, Camila F, Alonso, Juana, Rodriguez, Rosana, Jorge, Rodríguez-Castro, Villanueva, Antonio, Silva, Luis, Valencia, Jose Maria, Annona, Giovanni, Tarallo, Andrea, Ricardo, Fernando, Bratos-Cetinic, Ana, Posada, David, Pasantes, Juan Jose, MC Tubio, Jose |
| سنة النشر: |
2021 |
| المجموعة: |
Zenodo |
| الوصف: |
Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukemia-like transmissible cancers, called hemic neoplasias, have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight V. verrucosa clams that were diagnosed with hemic neoplasia, from two sampling points located more than 1,000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing of tumour tissues from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukemia originated in C. gallina (or a closely related taxa) and was later transmitted to V. verrucosa, in which it survived as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all the studied tumours belonging to a single neoplastic C. gallina lineage that spread in the Seas of Southern Europe. ; Funding provided by: European Research CouncilCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100000781AwardTest Number: Starting Grant 716290 SCUBA CANCERSFunding provided by: Spanish Ministry of Economy and CompetitivenessCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100010198AwardTest Number: BES-2016-078166Funding provided by: Xunta de GaliciaCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100010801AwardTest Number: ED481B/2018/091Funding provided by: European Research CouncilCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100000781AwardTest Number: ERC-617457- PHYLOCANCERFunding provided by: Spanish Ministry of Economy and CompetitivenessCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100010198AwardTest Number: PID2019- 106247GB-I00Funding provided by: ASSEMBLE Plus project*Crossref Funder Registry ID: Award Number: 730984 ; We performed whole-genome sequencing on 23 samples from 16 clam specimens, ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://zenodo.org/communities/dryadTest; https://zenodo.org/record/5796962Test; https://doi.org/10.5061/dryad.zcrjdfn9vTest; oai:zenodo.org:5796962 |
| DOI: |
10.5061/dryad.zcrjdfn9v |
| الإتاحة: |
https://doi.org/10.5061/dryad.zcrjdfn9vTest
https://zenodo.org/record/5796962Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/publicdomain/zero/1.0/legalcodeTest |
| رقم الانضمام: |
edsbas.A077DF82 |
| قاعدة البيانات: |
BASE |
