التفاصيل البيبلوغرافية
| العنوان: |
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria |
| المؤلفون: |
Zee, Tiffany, Bose, Neelanjan, Zee, Jarcy, Beck, Jennifer N., Yang, See, Parihar, Jaspreet, Yang, Min, Damodar, Sruthi, Hall, David, O'Leary, Monique N., Ramanathan, Arvind, Gerona, Roy R., Killilea, David W., Chi, Thomas, Tischfield, Jay, Sahota, Amrik, Kahn, Arnold, Stoller, Marshall L., Kapahi, Pankaj |
| سنة النشر: |
2017 |
| المجموعة: |
Zenodo |
| الوصف: |
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement a-lipoic acid inhibits cystine stone formation in the Slc3a1−/− mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
unknown |
| العلاقة: |
https://zenodo.org/record/1068345Test; https://doi.org/10.1038/nm.4280Test; oai:zenodo.org:1068345 |
| DOI: |
10.1038/nm.4280 |
| الإتاحة: |
https://doi.org/10.1038/nm.4280Test
https://zenodo.org/record/1068345Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.8A77593C |
| قاعدة البيانات: |
BASE |
