دورية أكاديمية
Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits is Co-operative and Cell-Specific
| العنوان: | Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits is Co-operative and Cell-Specific |
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| المؤلفون: | Yang, Danqing, Günte, Robert Heinz, Qi, Guanxiao, Radnikow, Gabriele, Feldmeyer, Dirk |
| المصدر: | Cerebral Cortex |
| سنة النشر: | 2020 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | barrel cortex, layer 6, pyramidal cells, acetylcholine, muscarinic receptors, nicotinic receptors, corticocortical, corticothalamic |
| الوصف: | Acetylcholine (ACh) is known to regulate cortical activity during different behavioral states, e.g. wakefulness and attention. Here we show a differential expression of muscarinic ACh receptors (mAChRs) and nicotinic AChRs (nAChRs) in different layer 6A (L6A) pyramidal cell (PC) types of somatosensory cortex. At low concentrations, ACh induced a persistent hyperpolarization in corticocortical (CC) but a depolarization in corticothalamic (CT) L6A PCs via M4 and M1 mAChRs, respectively. At ~1 mM ACh depolarized exclusively CT PCs via α4β2 subunit-containing nAChRs without affecting CC PCs. Miniature EPSC frequency in CC PCs was decreased by ACh but increased in CT PCs. In synaptic connections with a presynaptic CC PC, glutamate release was suppressed via M4 mAChR activation but enhanced by nAChRs via α4β2 nAChRs when the presynaptic neuron was a CT PC. Thus, in layer 6A the interaction of mAChRs and nAChRs results in an altered excitability and synaptic release, effectively strengthening corticothalamic output while weakening corticocortical synaptic signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/grantAgreement/EC/H2020/785907/; https://www.biorxiv.org/content/biorxiv/early/2019/09/02/701318.full.pdfTest; https://zenodo.org/record/3746629Test; https://doi.org/10.1093/cercor/bhz324Test; oai:zenodo.org:3746629 |
| DOI: | 10.1093/cercor/bhz324 |
| الإتاحة: | https://doi.org/10.1093/cercor/bhz324Test https://zenodo.org/record/3746629Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.C3D575B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cercor/bhz324 |
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