دورية أكاديمية
Cytosolic protection against ultraviolet induced DNA damage by blueberry anthocyanins and anthocyanidins in hepatocarcinoma HepG2 cells
| العنوان: | Cytosolic protection against ultraviolet induced DNA damage by blueberry anthocyanins and anthocyanidins in hepatocarcinoma HepG2 cells |
|---|---|
| المؤلفون: | Liu, Wei, Lu, Xiangyi, He, Guangyang, Gao, Xiang, Li, Mengxian, Wu, Junhua, Li, Zhenjing, Wu, Jihui, Wang, Juncheng, Luo, Cheng, 高兴, 贺光阳 |
| المصدر: | http://dx.doi.org/10.1007/s10529-012-1105-2Test. |
| بيانات النشر: | SPRINGER |
| سنة النشر: | 2013 |
| المجموعة: | Xiamen University Institutional Repository |
| مصطلحات موضوعية: | BREAKS |
| الوصف: | Tianjin city government for "1000 talents plan" program ; UV-induced DNA damage plays a key role in the etiology of certain diseases. The ability of blueberry anthocyanins and anthocyanidins (BA) to protect cellular DNA from UV-induced damage was investigated. BA were extracted by water (BAW), ethanol (BAE) or methanol (BAM). These extracts partially restored proliferation of UV-irradiated HepG2 cells as shown by MTT assay. Treatment with BA extracts at 75 mu g/ml decreased reactive oxygen species and decreased DNA damage by tail moment of comet assay and expression of gamma H2AX in situ. BAM significantly decreased gene and protein expression of p53, phospho-p53 (Ser15), and p21 in UV-irradiated HepG2 cells. BA thus efficiently protects cells from DNA damage in vitro. Blueberry may potentially be used as a good source of naturally radioprotective agents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | BIOTECHNOLOGY LETTERS, 2013,35(4):491-498; WOS:000316081800003; http://dspace.xmu.edu.cn/handle/2288/93572Test |
| الإتاحة: | https://doi.org/10.1007/s10529-012-1105-2Test http://dspace.xmu.edu.cn/handle/2288/93572Test |
| رقم الانضمام: | edsbas.74693DC5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |