التفاصيل البيبلوغرافية
العنوان: |
交通性脑积水大鼠模型纤维化发生机制及pHGF抗纤维化研究 ; Study on the fibrosis mechanism of communicating hydrocephalus induced following intra-ventricular kaolin injection in adult rats and the effect of anti-fibrosis therapy with the pHGF |
المؤلفون: |
张绍林 |
المساهمون: |
王占祥, 谭国伟、刘希尧 |
المصدر: |
http://210.34.4.13:8080/lunwen/detail.asp?serial=36599Test. |
سنة النشر: |
2012 |
المجموعة: |
Xiamen University Institutional Repository |
مصطلحات موضوعية: |
Hydrocephalus, Fibrosis, Anti-fibrosis, TGF-β1, HGF, MMP-9, 脑积水, 纤维化, 抗纤维化 |
الوصف: |
目的:研究交通性脑积水大鼠模型纤维化发生机制以及pHGF抗脑积水纤维化作用。 方法:雄性SD大鼠(250±10g),随机分成4组:生理盐水对照组,脑积水组,阴性干预对照组(生理盐水干预)和pHGF干预组,每组15只。脑积水组采用侧脑室注射3%高岭土混悬液制备交通性脑积水模型;对照组给予生理盐水注射;pHGF干预组:3%高岭土混悬注射后同时给予pHGF微渗透泵(pHGF浓度40mg/ml)干预;阴性干预对照组:3%高岭土混悬注射后给予生理盐水微渗透泵。10天后对4组分别进行Morris水迷宫实验,第15天行MRI检测,然后收集脑脊液,处死动物,收集脑组织标本,行HE、免疫组化、Elisa和RT. ; Purpose:This study attempted to investigate the mechanism of the fibrosis of communicating hydrocephalus induced following intra-ventricular kaolin injection in adult rats and the effect of anti-fibrosis therapy with the pHGF. Methods: Adult male Sprague-Dawley rats (250 ±10g) were randomly divided into 4 groups: control group (n=15), hydrocephalic group (n=15), saline treatment group (n=15) and. ; 学位:医学硕士 ; 院系专业:医学院临床医学系_外科学 ; 学号:24520091152995 |
نوع الوثيقة: |
thesis |
اللغة: |
Chinese |
العلاقة: |
http://210.34.4.28/opac/openlink.php?strText=35514&doctype=ALL&strSearchType=callnoTest; http://dspace.xmu.edu.cn/handle/2288/52235Test |
الإتاحة: |
http://dspace.xmu.edu.cn/handle/2288/52235Test |
رقم الانضمام: |
edsbas.F662F183 |
قاعدة البيانات: |
BASE |